Literature DB >> 4434089

Haemoglobin Belfast 15 (A12) tryptophan leading to arginine: a new unstable haemoglobin variant.

C C Kennedy, G Blundell, P A Lorkin, A Lang, H Lehmann.   

Abstract

A new unstable haemoglobin, alpha(2)beta(2)15 Trp--> Arg (Hb Belfast), with increased oxygen affinity has been found during the routine investigation of a long-stay psychiatric patient. It seemed to cause little haematological disorder. The reticulocytes synthesized normal and abnormal beta-chains at the same rate but in the circulating blood Hb Belfast amounted to only 27.5% of the total haemoglobin.

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Year:  1974        PMID： 4434089      PMCID： PMC1612879          DOI： 10.1136/bmj.4.5940.324

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  8 in total

1.  STUDIES ON HEMOGLOBIN BIOSYNTHESIS: ASYNCHRONOUS SYNTHESIS OF HEMOGLOBIN A AND HEMOGLOBIN A2 BY ERYTHROCYTE PRECURSORS.

Authors:  R F RIEDER; D J WEATHERALL
Journal:  J Clin Invest       Date:  1965-01       Impact factor: 14.808

Review 2.  The unstable hemoglobins (congenital Heinz body hemolytic anemia).

Authors:  H F Bunn
Journal:  Am J Med Technol       Date:  1973-10

3.  Hemoglobin Duarte: (alpha2beta2 62(E6)Ala leads to Pro): a new unstable hemoglobin with increased oxygen affinity.

Authors:  E Beutler; A Lang; H Lehmann
Journal:  Blood       Date:  1974-04       Impact factor: 22.113

4.  Differentiation of iron deficiency from thalassaemia trait by routine blood-count.

Authors:  J M England; P M Fraser
Journal:  Lancet       Date:  1973-03-03       Impact factor: 79.321

5.  Some aspects of the haemoglobinopathies.

Authors:  H Lehmann
Journal:  Trans R Soc Trop Med Hyg       Date:  1974       Impact factor: 2.184

6.  Synthesis of Hb Lepore ( 2 2 ): influence of and nucleotide sequence on synthesis of chain.

Authors:  A Lang; J M White; H Lehmann
Journal:  Nat New Biol       Date:  1972-12-27

7.  A simple method for the detection of unstable haemoglobins.

Authors:  R W Carrell; R Kay
Journal:  Br J Haematol       Date:  1972-11       Impact factor: 6.998

8.  Studies on the function of abnormal hemoglobins. I. An improved method for automatic measurement of the oxygen equilibrium curve of hemoglobin.

Authors:  K Imai; H Morimoto; M Kotani; H Watari; W Hirata
Journal:  Biochim Biophys Acta       Date:  1970-02-17
  8 in total
  2 in total

1.  Hb Baden: structural and functional characterization.

Authors:  Osheiza Abdulmalik; Martin K Safo; Steven H Seeholzer; Toshio Asakura; Nicole C Hasbrouck; J Eric Russell
Journal:  Am J Hematol       Date:  2010-11       Impact factor: 10.047

Review 2.  Thalassemic hemoglobinopathies.

Authors:  M H Steinberg; J G Adams
Journal:  Am J Pathol       Date:  1983-12       Impact factor: 4.307
  2 in total

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