Literature DB >> 4432067

Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism.

J Imperato-McGinley, L Guerrero, T Gautier, R E Peterson.   

Abstract

In male pseudohermaphrodites born with ambiguity of the external genitalia but with marked virilization at puberty, biochemical evaluation reveals a marked decrease in plasma dihydrotestosterone secondary to a decrease in steroid 5alpha-reductase activity. In utero the decrease in dihydrotestosterone results in incomplete masculinization of the external genitalia. Inheritance is autosomal recessive.

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Year:  1974        PMID： 4432067     DOI： 10.1126/science.186.4170.1213

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  169 in total

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Review 5.  The role of 5-alpha-reductase inhibition as monotherapy in view of the MTOPS data.

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9.  Unexpected virilization in male mice lacking steroid 5 alpha-reductase enzymes.

Authors:  M S Mahendroo; K M Cala; D L Hess; D W Russell
Journal:  Endocrinology       Date:  2001-11       Impact factor: 4.736

10.  Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors.

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