Further progress with oncolysis due to apathogenic clostridia.

Cl. onc. apathogenic for human beings and small animals is not able to cure tumor-bearing hosts. Combined treatments with local X-irradiation and local HFH have decreased the death rate of Harding-Passey-Melanoma-bearing mice. A cure rate of ca. 20% has resulted for the first time in such experiments. The survival time has increased significantly, however relapses occured on the sites of transplantation which finally killed the animals. Therefore it was tried to repeat the threefold-combined treatment. The animals with a relapse tolerated such a second and third series well. After the second series of treatment some animals became free of relapse and some after the third series. That means, if repeating treatment with local HFH, local X-irradiation, and i.v. spore-application of Cl. onc., it is possible to cure the Harding-Passey-Melanoma of the mouse at a high percentage.