Literature DB >> 442215

VP-16, cyclophosphamide, adriamycin and cis-platinum (V:CAP-I) in patients with metastatic adenocarcinoma of the lung.

R T Eagan, E T Creagan, J N Ingle, J Rubin, S Frytak, L K Kvols, T R Fleming.   

Abstract

In an attempt to improve upon the 42% regression rate of the CAP-I regimen in patients with advanced adenocarcinoma of the lung, VP-16 was added to that regimen. VP-16, as a single agent, had a response rate of 12.5% (3/24) In a similar group of patients. The new regimen, V:CAP-I, had a tumor regression rate of 35% (7/20) and an estimated median survival of 171 days. Hence, we were unable to conclude that the addition of VP-16 to the CAP-I regimen statistically improved the regression rate of the CAP-I regimen.

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Year:  1979        PMID: 442215     DOI: 10.1177/030089167906500112

Source DB:  PubMed          Journal:  Tumori        ISSN: 0300-8916


  2 in total

Review 1.  Combination chemotherapy for advanced adenocarcinoma of the lung. A review.

Authors:  J B Sørensen; H H Hansen
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333

2.  Phase II trial of VP16-213 in non-small cell lung cancer (NSCLC).

Authors:  R Chapman; L Itri; R Gralla; D Kelsen; E Casper; R Golbey
Journal:  Cancer Chemother Pharmacol       Date:  1982       Impact factor: 3.333

  2 in total

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