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Literature DB >> 44190

Properties of the two common electrophoretic variants of phosphoglucomutase in Drosophila melanogaster.

L Fucci, L Gaudio, R Rao, A Spanò, M Carfagna.

Abstract

Phosphoglucomutase (PGM) of adult stage in Drosophilia melanogaster has been characterized by gel filtration, ion-exchange chromatography, and isoelectric focusing. The two common electrophoretic variants, PGMA and PGMB, differ with respect to their kinetic and stability parameters. PGMA is more thermostable than PGMB but shows the same pH optimum, equal dependence on Mg2+, and identical molecular weight. There is no significant kinetic difference between the two allozymes at the optimum pH values, but at pH 6.0 the Km value for glucose-1,6-diphosphate of PGMB is significantly higher than that of PGMA. This difference might explain the observed selective advantage of the PgmA allele in population studies.

Entities: Chemical Gene Species

Mesh：

Substances：
Phosphoglucomutase

Year: 1979 PMID： 44190 DOI： 10.1007/bf00504306

Source DB: PubMed Journal: Biochem Genet ISSN： 0006-2928 Impact factor: 1.890

17 in total

1. Population size and natural selection in the land snail Cepaea nemoralis.

Authors: P F Brussard
Journal: Nature Date: 1974-10-25 Impact factor: 49.962

2. Isoelectric focusing of lens crystallins in thin-layer polyacrylamide gels. A method for detection of soluble proteins in eye lens extracts.

Authors: J Bours
Journal: J Chromatogr Date: 1971-08-26

3. A third phosphoglucomutase locus in man.

Authors: D A Hopkinson; H Harris
Journal: Ann Hum Genet Date: 1968-05 Impact factor: 1.670

4. Thermostability studies on the isozymes of human phosphoglucomutase.

Authors: P J McAlpine; D A Hopkinson; H Harris
Journal: Ann Hum Genet Date: 1970-07 Impact factor: 1.670

5. Phosphoglucomutase. V. Multiple forms of phosphoglucomutase.

Authors: J G Joshi; J Hooper; T Kuwaki; T Sakurada; J R Swanson; P Handler
Journal: Proc Natl Acad Sci U S A Date: 1967-05 Impact factor: 11.205

6. Thermostability studies for investigating non-electrophoretic polymorphic alleles in Drosophila melanogaster.

Authors: G Trippa; A Loverre; A Catamo
Journal: Nature Date: 1976-03-04 Impact factor: 49.962

7. A phosphoglucomutase locus in Drosophila melanogaster.

Authors: J P Hjorth
Journal: Hereditas Date: 1970 Impact factor: 3.271

8. Fitness of allozyme variants in Drosophila pseudoobscura. I. Selection at the PGM-1 and Me-2 loci.

Authors: D Marinković; F J Ayala
Journal: Genetics Date: 1975-01 Impact factor: 4.562

9. Phosphoglucomutase polymorphism in white shrimp, Penaeus setiferus.

Authors: K T Marvin; C W Caillouet
Journal: Comp Biochem Physiol B Date: 1976

10. Phosphoglucomutase (PGM) locus in Drosophila melanogaster: linkage and population data.

Authors: G Trippa; C Santolamazza; R Scozzari
Journal: Biochem Genet Date: 1970-12 Impact factor: 1.890

6 in total

1. Extensive amino acid polymorphism at the pgm locus is consistent with adaptive protein evolution in Drosophila melanogaster.

Authors: B C Verrelli; W F Eanes
Journal: Genetics Date: 2000-12 Impact factor: 4.562