Literature DB >> 4414773

N'-nitrosonornicotine in tobacco.

D Hoffmann, S S Hecht, R M Ornaf, E L Wynder.   

Abstract

N'-Nitrosonornicotine, a potential carcinogen, has been positively identified in unburned tobacco. The amount in commercial U.S. tobacco products is between 1.9 to 88.6 parts per million, one of the highest values of an environmental nitrosamine yet reported. The amount in food and drink rarely exceeds 0.1 part per million. This compound is the first example of a potential organic carcinogen isolated from tobacco.

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Year:  1974        PMID: 4414773     DOI: 10.1126/science.186.4160.265

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  15 in total

Review 1.  Evolution of research on the DNA adduct chemistry of N-nitrosopyrrolidine and related aldehydes.

Authors:  Stephen S Hecht; Pramod Upadhyaya; Mingyao Wang
Journal:  Chem Res Toxicol       Date:  2011-04-21       Impact factor: 3.739

2.  A reorganised medical division.

Authors:  J H Friend
Journal:  Br Med J       Date:  1978-06-24

3.  Development of a heart-cutting supercritical fluid chromatography-high-performance liquid chromatography coupled to tandem mass spectrometry for the determination of four tobacco-specific nitrosamines in mainstream smoke.

Authors:  Yan Zhou; Haobo Zhang; Xianying Wang; Dawei Qi; Wenbo Gu; Da Wu; Baizhan Liu
Journal:  Anal Bioanal Chem       Date:  2019-03-15       Impact factor: 4.142

4.  It is time to regulate carcinogenic tobacco-specific nitrosamines in cigarette tobacco.

Authors:  Stephen S Hecht
Journal:  Cancer Prev Res (Phila)       Date:  2014-05-07

5.  Tobacco nitrosamine N-nitrosonornicotine as inhibitor of neuronal nicotinic acetylcholine receptors.

Authors:  Ariane Nunes-Alves; Arthur A Nery; Henning Ulrich
Journal:  J Mol Neurosci       Date:  2012-07-31       Impact factor: 3.444

6.  Environmental causes of childhood brain tumours.

Authors:  Olufemi E Idowu; Mopelola A Idowu
Journal:  Afr Health Sci       Date:  2008-03       Impact factor: 0.927

7.  (S)-N'-Nitrosonornicotine, a constituent of smokeless tobacco, is a powerful oral cavity carcinogen in rats.

Authors:  Silvia Balbo; Sandra James-Yi; Charles S Johnson; Michael G O'Sullivan; Irina Stepanov; Mingyao Wang; Dipankar Bandyopadhyay; Fekadu Kassie; Steven Carmella; Pramod Upadhyaya; Stephen S Hecht
Journal:  Carcinogenesis       Date:  2013-05-13       Impact factor: 4.944

8.  Cancer epidemiology: the Indian scene.

Authors:  L D Sanghvi
Journal:  J Cancer Res Clin Oncol       Date:  1981       Impact factor: 4.553

9.  Tobacco Smoke-Induced Brain White Matter Myelin Dysfunction: Potential Co-Factor Role of Smoking in Neurodegeneration.

Authors:  Rosa Yu; Chetram Deochand; Alexander Krotow; Raiane Leão; Ming Tong; Amit R Agarwal; Enrique Cadenas; Suzanne M de la Monte
Journal:  J Alzheimers Dis       Date:  2016       Impact factor: 4.472

10.  Autoradiographic observations on the distribution and metabolism of N'-/14C/nitrosonornicotine in mice.

Authors:  E Brittebo; H Tjälve
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553

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