Literature DB >> 441430

Cancer growth, response to treatment and survival time in mice: beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen.

A Bennett, J Houghton, D J Leaper, I F Stamford.   

Abstract

Adult mice were injected subcutaneously with cells from a syngeneic metastasizing mammary cancer. Daily treatment with flurbiprofen starting before injection of the cancer cells reduced tumour growth and lengthened the survival of mice whose tumours were excised at 3 weeks. When low doses of radiotherapy and chemotherapy were given, additional treatment with flurbiprofen starting 25 days after injecting the cancer cells substantially inhibited tumour growth.

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Year:  1979        PMID: 441430     DOI: 10.1016/0090-6980(79)90037-6

Source DB:  PubMed          Journal:  Prostaglandins        ISSN: 0090-6980


  19 in total

1.  COX-1 and COX-2 products in the gut: therapeutic impact of COX-2 inhibitors.

Authors:  B J Whittle
Journal:  Gut       Date:  2000-09       Impact factor: 23.059

2.  Effects of sulindac on sporadic colorectal adenomatous polyps.

Authors:  N Matsuhashi; A Nakajima; Y Fukushima; Y Yazaki; T Oka
Journal:  Gut       Date:  1997-03       Impact factor: 23.059

3.  Endogenous prostaglandin production by established cultures of neoplastic rat mammary epithelial cells.

Authors:  L A Cohen; R A Karmali
Journal:  In Vitro       Date:  1984-02

4.  Inhibition of tumor growth and metastasis by chronic intravenous infusion of prostaglandin E1.

Authors:  L M Ellis; E M Copeland; K I Bland; H S Sitren
Journal:  Ann Surg       Date:  1990-07       Impact factor: 12.969

5.  Thrombocytopenia provoked by carrageenan in rabbits and the inhibitory effect of lysozyme.

Authors:  C Bianchi
Journal:  Agents Actions       Date:  1982-12

6.  Studies on the mechanism by which indomethacin increases the anticancer effect of methotrexate.

Authors:  A Bennett; J D Gaffen; P B Melhuish; I F Stamford
Journal:  Br J Pharmacol       Date:  1987-05       Impact factor: 8.739

Review 7.  Regulation of the immune response by prostaglandins.

Authors:  J S Goodwin; J Ceuppens
Journal:  J Clin Immunol       Date:  1983-10       Impact factor: 8.317

8.  Growth inhibition of transplantable murine colon adenocarcinoma 38 by indomethacin.

Authors:  M Sato; T Narisawa; M Sano; T Takahashi; A Goto
Journal:  J Cancer Res Clin Oncol       Date:  1983       Impact factor: 4.553

9.  The effects of indomethacin and interleukin-2 on the proliferation of lymphocytes from patients with lung cancer.

Authors:  R D Maca; J G Burford; R T Taylor
Journal:  J Clin Immunol       Date:  1985-05       Impact factor: 8.317

Review 10.  Potential therapeutic applications of aspirin and other cyclo-oxygenase inhibitors.

Authors:  A E Farah; F Rosenberg
Journal:  Br J Clin Pharmacol       Date:  1980-10       Impact factor: 4.335

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