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Literature DB >> 4413876

Influence of DEAE-dextran, polybrene, dextran and dextran sulphate on spontaneous leukaemia development in AKR mice and virus induced leukaemia in BALB-c mice.

Abstract

AKR mice of which more than 90% die of lymphatic thymus leukaemia, had their mean survival time increased by weekly intraperitoneal inoculation of either of the two polycations DEAE-dextran and polybrene. Administration of the neutral dextran had no effect, whereas the polyanion dextran sulphate accelerated leukaemia development.Adult BALB/c mice infected with Rauscher leukaemia virus and treated from the time of palpable spleen enlargement, showed a life prolonging effect of the polycations DEAE/dextran and polybrene, and of neutral dextran. BALB/c mice treated from the time of leukaemia infection, however, showed a life prolonging effect with polyanion dextran sulphate and also of neutral dextran.

Entities: Chemical Disease Species

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Year: 1974 PMID： 4413876 PMCID： PMC2009190 DOI： 10.1038/bjc.1974.114

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

16 in total

1. Differences between the electrical charge carried by normal and homologous tumour cells.

Authors: A M JAMES; E J AMBROSE; J H LOWICK
Journal: Nature Date: 1956-03-24 Impact factor: 49.962

2. Normal and pathologic anatomy of the reticular tissue in laboratory mice, with a classification and discussion of neoplasms.

Authors: T B DUNN
Journal: J Natl Cancer Inst Date: 1954-06 Impact factor: 13.506

Influence of DEAE-dextran, polybrene, dextran and dextran sulphate on spontaneous leukaemia development in AKR mice and virus induced leukaemia in BALB-c mice.

1. Differences between the electrical charge carried by normal and homologous tumour cells.

2. Normal and pathologic anatomy of the reticular tissue in laboratory mice, with a classification and discussion of neoplasms.

3. DEAE-dextran enhancement of in vivo infection with murine leukemia virus.

4. DEAE-dextran and polybrene cation enhancement and dextran sulfate anion inhibition of immune cytolysis.

5. In vivo enhancement of a murine sarcoma virus by diethylaminoethyl-dextran.

6. Thymus-dependent and thymus-independent lymphocyte separation: relation to exposed sialic acid on cell surface.

7. Oncogenic water-soluble polycations. 1. Induction of sarcomas in mice by diethylaminoethyl-dextran.

8. Inhibitory effect of polycations on the transplantability of mouse leukaemia reversed by heparin.

9. Plaque assay techniques for murine leukemia viruses.

10. Quantitative studies of naturally occurring murine leukemia virus infection of AKR mice.

1. Mechanism of the anti-tumour effect of glucans and fructosans: a comparison with C. parvum.

2. Chalone-like effect abrogated by dextran sulphate and heparin polyanion pretreatment of target cells.

3. Life span, leukaemia and amyloid incidences of untreated and polycation-treated AKR mice.