Literature DB >> 4407283

Serum alpha-fetoprotein: diagnostic significance in liver disease.

E Ruoslahti, M Salaspuro, H Pihko, L Andersson, M Seppälä.   

Abstract

Raised serum alpha-fetoprotein levels measured by radioimmunoassay were found in 19 out of 24 (79%) patients with primary liver cancer and in 32 out of 311 (10%) patients with other liver diseases. The rise was transient in cases of hepatitis and a transient rise was also seen after alcohol intake ceased in two patients with cirrhosis. alpha-Fetoprotein levels exceeding 500 ng/ml were 30-50 times more common in primary liver cancer than in other liver diseases. A rise in level seems to reflect the extent of liver regeneration in liver diseases other than primary cancer.

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Year:  1974        PMID: 4407283      PMCID: PMC1610895          DOI: 10.1136/bmj.2.5918.527

Source DB:  PubMed          Journal:  Br Med J        ISSN: 0007-1447


  8 in total

1.  [Radioimmunoassay of alpha-fetoprotein in primary and secondary cancer of the liver].

Authors:  E Ruoslahti; M Seppälä; P Vuopio; E Saksela; P Peltokallio
Journal:  J Natl Cancer Inst       Date:  1972-09       Impact factor: 13.506

2.  Dependence of the specificity of the serologic test for primary liver cancer in different areas of the world on sensitivity of the method used for detecting alpha-fetoprotein.

Authors:  D A Elgort; G I Abelev; G T O'Conor
Journal:  Int J Cancer       Date:  1972-09-15       Impact factor: 7.396

3.  Alpha-fetoprotein and hepatitis B antigen in acute hepatitis and primary cancer of the liver.

Authors:  E Ruoslahti; M Seppälä; J A Räsänen; P Vuopio; T Helske
Journal:  Scand J Gastroenterol       Date:  1973       Impact factor: 2.423

4.  Radioimmunoassay of alpha-fetoprotein in human plasma.

Authors:  J A Chayvialle; P C Ganguli
Journal:  Lancet       Date:  1973-06-16       Impact factor: 79.321

5.  Normal and increased alpha-fetoprotein in neoplastic and non-neoplastic liver disease.

Authors:  E Ruoslahti; M Seppälä
Journal:  Lancet       Date:  1972-08-05       Impact factor: 79.321

Review 6.  Alpha-fetoprotein in ontogenesis and its association with malignant tumors.

Authors:  G I Abelev
Journal:  Adv Cancer Res       Date:  1971       Impact factor: 6.242

7.  Alpha-fetoprotein in normal and pregnancy sera.

Authors:  M Seppälä; E Ruoslahti
Journal:  Lancet       Date:  1972-02-12       Impact factor: 79.321

8.  Studies of carcino-fetal proteins. 3. Development of a radioimmunoassay for -fetoprotein. Demonstration of -fetoprotein in serum of healthy human adults.

Authors:  E Ruoslahti; M Seppälä
Journal:  Int J Cancer       Date:  1971-11-15       Impact factor: 7.396

  8 in total
  22 in total

1.  Differentiation of acute and chronic hepatitis B in IgM anti-HBc positive patients.

Authors:  Ji Won Park; Kyeong Min Kwak; Sung Eun Kim; Myoung Kuk Jang; Dong Joon Kim; Myung Seok Lee; Hyoung Su Kim; Choong Kee Park
Journal:  World J Gastroenterol       Date:  2015-04-07       Impact factor: 5.742

2.  Multiple malignant neoplasms 40 years after angiography with Thorotrast.

Authors:  P Silpananta; F F Illescas; H Sheldon
Journal:  Can Med Assoc J       Date:  1983-02-01       Impact factor: 8.262

3.  Total serum glycan analysis is superior to lectin-FLISA for the early detection of hepatocellular carcinoma.

Authors:  Mary Ann Comunale; Mengjun Wang; Nikhil Anbarasan; Lucy Betesh; Aykan Karabudak; Ethan Moritz; Karthik Devarajan; Jorge Marrero; Timothy M Block; Anand Mehta
Journal:  Proteomics Clin Appl       Date:  2013-09-13       Impact factor: 3.494

4.  [Alpha-fetoprotein and cystic fibrosis (author's transl)].

Authors:  T Lücking; P Mariss
Journal:  Klin Wochenschr       Date:  1976-04-15

5.  Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinoma.

Authors:  Mary Ann Comunale; Lucy Rodemich-Betesh; Julie Hafner; Mengjun Wang; Pamela Norton; Adrian M Di Bisceglie; Timothy Block; Anand Mehta
Journal:  PLoS One       Date:  2010-08-25       Impact factor: 3.240

6.  Hepatoma causing a massive tumour embolus.

Authors:  Y F Dajani
Journal:  Postgrad Med J       Date:  1977-07       Impact factor: 2.401

7.  Novel fucosylated biomarkers for the early detection of hepatocellular carcinoma.

Authors:  Mengjun Wang; Ronald E Long; Mary Ann Comunale; Omer Junaidi; Jorge Marrero; Adrian M Di Bisceglie; Timothy M Block; Anand S Mehta
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2009-05-19       Impact factor: 4.254

8.  Cholic acid, chenodeoxycholic acid, alpha-1-fetoprotein and alpha-1-antitrypsin serum concentrations in breast-fed infants with prolonged jaundice.

Authors:  K Finni; S Similä; M Koivisto; S Heikura; M Ala-Houhala
Journal:  Eur J Pediatr       Date:  1982-02       Impact factor: 3.183

9.  Alcoholic liver disease. Absence of alpha-fetoprotein elevations in the recovery phase.

Authors:  T E Noble; J Galdabini; R M Resnik; E Alpert
Journal:  Dig Dis Sci       Date:  1980-04       Impact factor: 3.199

10.  Tumor marker requests in a general teaching Turkish hospital.

Authors:  Gülsen Yilmaz; Fatma Meriç Yilmaz; Mehmet Senes; Dogan Yucel
Journal:  Indian J Clin Biochem       Date:  2007-03
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