Literature DB >> 4404396

The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat.

M K Church, H O Collier, G W James.   

Abstract

1. A method for the measurement of anaphylactic bronchoconstriction in the rat is described.2. Dexamethasone inhibited this response in a dose-related manner.3. Disodium cromoglycate antagonized the response. A bell-shaped dose-response curve was obtained with peak activity at 1 mg/kg i.v.4. Meclofenamate was not active when given alone or in combination with dexamethasone.5. Methysergide significantly inhibited the response. Mepyramine, atropine, propranolol and adrenalectomy did not significantly modify the response.6. The relationships of anaphylactic bronchoconstriction in the rat to anaphylactic bronchoconstriction in the guinea-pig and to human asthma are discussed.

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Year:  1972        PMID： 4404396      PMCID： PMC1666102          DOI： 10.1111/j.1476-5381.1972.tb06848.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  41 in total

1.  Actions of some peptides on bronchial muscle.

Authors:  K D BHOOLA; H O COLLIER; M SCHACHTER; P G SHORLEY
Journal:  Br J Pharmacol Chemother       Date:  1962-08

2.  The protective action of antihistaminic and sympathomimetic aerosols in anaphylactic microshock of the guinea-pig.

Authors:  H HERXHEIMER
Journal:  Br J Pharmacol Chemother       Date:  1953-12

3.  The protective action of antihistamines in the anaphylactic microshock of the guinea-pig.

Authors:  P ARMITAGE; H HERXHEIMER; L ROSA
Journal:  Br J Pharmacol Chemother       Date:  1952-12

4.  Release of histamine and slow reacting substance with mast cell changes after challenge of human lung sensitized passively with reagin in vitro.

Authors:  W E Parish
Journal:  Nature       Date:  1967-08-12       Impact factor: 49.962

5.  A method for measurement and statistical analysis of large numbers of experimental tracings.

Authors:  A H Christianson; L C Dinneen; G W James; A C Perkins
Journal:  J Pharm Pharmacol       Date:  1967-12       Impact factor: 3.765

6.  Disodium cromoglycate (FPL 670) ('Intal'): a specific inhibitor of reaginic antibody-antigen mechanisms.

Authors:  J S Cox
Journal:  Nature       Date:  1967-12-30       Impact factor: 49.962

Review 7.  Prostaglandins and aspirin.

Authors:  H O Collier
Journal:  Nature       Date:  1971-07-02       Impact factor: 49.962

8.  Antigen induced release of histamine and SRS-A from human lung passively sensitized with reaginic serum.

Authors:  P Sheard; P G Killingback; A M Blair
Journal:  Nature       Date:  1967-10-21       Impact factor: 49.962

9.  Dexamethasone and dexamethasone-aspirin in the treatment of chronic rheumatoid arthritis. A controlled trial.

Authors:  H Jick; R S Pinals; R Ullian; D Slone; H Muench
Journal:  Lancet       Date:  1965-12-11       Impact factor: 79.321

10.  BRONCHOCONSTRICTOR ACTION AND ANTAGONISM OF A SLOW-REACTING SUBSTANCE FROM ANAPHYLAXIS OF GUINEA-PIG ISOLATED LUNG.

Authors:  P A BERRY; H O COLLIER
Journal:  Br J Pharmacol Chemother       Date:  1964-08
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  19 in total

1.  Inhibition by glucocorticoids of the mast cell-dependent weal and flare response in human skin in vivo.

Authors:  Z A Cole; G F Clough; M K Church
Journal:  Br J Pharmacol       Date:  2001-01       Impact factor: 8.739

2.  Pharmacologic properties of FPL 55712 administered by aerosol.

Authors:  M O'Donnell; A F Welton
Journal:  Agents Actions       Date:  1984-01

3.  The respiratory response in sensitized rats to aerosol challenge.

Authors:  F Carswell; J Oliver
Journal:  Immunology       Date:  1978-03       Impact factor: 7.397

4.  Immediate inhibitory effect of methylprednisolone suleptanate (U-67590A) on antigen-induced cutaneous and airway anaphylactic responses in guinea-pigs.

Authors:  M Hashimoto; Y Shinozaki; M Katori
Journal:  Br J Pharmacol       Date:  1993-03       Impact factor: 8.739

5.  The effect of prednisolone and ketotifen on the antigen-induced bronchoconstriction and mediator release in rat isolated lungs.

Authors:  M Ottenhof; J G Ufkes; H H Van Rooij
Journal:  Br J Pharmacol       Date:  1985-11       Impact factor: 8.739

6.  Mediators of passive lung anaphylaxis in the rat.

Authors:  J B Farmer; I M Richards; P Sheard; A M Woods
Journal:  Br J Pharmacol       Date:  1975-09       Impact factor: 8.739

7.  Time courses of the anti-anaphylactic and anti-inflammatory effects of dexamethasone in the rat and mouse.

Authors:  M K Church; P Miller
Journal:  Br J Pharmacol       Date:  1978-04       Impact factor: 8.739

8.  Modification by betamethasone of the effects of bronchodilator drugs on cholinergic bronchoconstriction in rats.

Authors:  M J Mattila; R O Salonen
Journal:  Br J Pharmacol       Date:  1984-11       Impact factor: 8.739

9.  The influence of a new corticosteroid, budesonide, on anaphylactic bronchoconstriction and SRS-A release in the guinea pig.

Authors:  K Forsberg; L Sörenby
Journal:  Agents Actions       Date:  1981-07

10.  An in vitro study of various drugs on central and peripheral airways of the rat: a comparison with human airways.

Authors:  K M Lulich; J W Paterson
Journal:  Br J Pharmacol       Date:  1980-04       Impact factor: 8.739
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