Literature DB >> 4403685

Fluorometric estimation of 4-hydroxy-3-methoxyphenylethyleneglycol sulphate in brain.

J L Meek, N H Neff.   

Abstract

1. A simple, sensitive, and selective method was developed for the fluorimetric estimation of 4-hydroxy-3-methoxyphenylethyleneglycol sulphate (MOPEG-SO(4)) in rat brain.2. MOPEG-SO(4) was isolated on a DEAE Sephadex column. Fluorescence was measured at 465 nm (excitation at 320 nm) after heating the column eluate with acid and reheating after adding ethylene diamine.3. The concentration in brain of MOPEG-SO(4) increased after blockade of its transport from brain by treatment with probenecid and decreased after inhibiting its synthesis by treatment with alpha-methyltyrosine or pargyline.4. Our studies suggest that measurement in changes in the rate of formation of MOPEG-SO(4) may be a useful index of noradrenaline turnover.

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Year:  1972        PMID： 4403685      PMCID： PMC1666152          DOI： 10.1111/j.1476-5381.1972.tb08099.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  3 -Methoxy- 4 -hydroxyphenylethylene glycol in human cerebrospinal fluid.

Authors:  E K Gordon; J Oliver
Journal:  Clin Chim Acta       Date:  1971-11       Impact factor: 3.786

2.  3-methoxy-4-hydroxyphenylglycol sulfate in brain and cerebrospinal fluid.

Authors:  S M Schanberg; G R Breese; K K Schildkraut; E K Gordon; I J Kopin
Journal:  Biochem Pharmacol       Date:  1968-09       Impact factor: 5.858

3.  Effect of intravenously administered probenecid in humans on the levels of 5-hydroxyindoleacetic acid, homovanillic acid and 3-methoxy-4-hydroxy-phenylglycol in cerebrospinal fluid.

Authors:  J Korf; H M van Praag; J B Sebens
Journal:  Biochem Pharmacol       Date:  1971-03       Impact factor: 5.858

4.  Metabolism of normetanephrine-H3 in rat brain--identification of conjugated 3-methoxy-4-hydrophenylglycol as the major metabolite.

Authors:  S M Schanberg; J J Schildkraut; G R Breese; I J Kopin
Journal:  Biochem Pharmacol       Date:  1968-02       Impact factor: 5.858

5.  Determination of urinary 3-methoxy-4-hydroxyphenyl-ethylene glycol by gas-liquid chromatography and electron capture detection.

Authors:  S Wilk; S E Gitlow; D D Clarke; D H Paley
Journal:  Clin Chim Acta       Date:  1967-06       Impact factor: 3.786

6.  Glycol metabolites of noradrenaline in brain tissue.

Authors:  D F Sharman
Journal:  Br J Pharmacol       Date:  1969-07       Impact factor: 8.739

7.  Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.

Authors:  J Glowinski; L L Iversen
Journal:  J Neurochem       Date:  1966-08       Impact factor: 5.372
  7 in total
  24 in total

1.  Presynaptic receptor systems on the noradrenergic neurones of rat brain.

Authors:  H D Taube; K Starke; E Borowski
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-09       Impact factor: 3.000

2.  Bromocriptine, dihydroergotoxine, methysergide, d-LSD, CF25--397, and 29--712: effects on the metabolism of the biogenic amines in the brain of the rat.

Authors:  H R Bürki; H Asper; W Ruch; P E Züger
Journal:  Psychopharmacology (Berl)       Date:  1978-05-31       Impact factor: 4.530

3.  Binding of psychoactive drugs to rat brain amine receptors, measured ex vivo, and their effects on the metabolism of biogenic amines.

Authors:  H R Burki
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-03       Impact factor: 3.000

4.  Effect of aging on monoamines and their metabolites in the rat brain.

Authors:  A Moretti; N Carfagna; F Trunzo
Journal:  Neurochem Res       Date:  1987-11       Impact factor: 3.996

5.  Effect of a new benzodiazepine bromazepam on locomotor performance and brain monoamine metabolism.

Authors:  R B Rastogi; Y D Lapierre; R L Singhal
Journal:  J Neural Transm       Date:  1978       Impact factor: 3.575

6.  Effects of thyroid status on presynaptic alpha 2-adrenoceptor function and beta-adrenoceptor binding in the rat brain.

Authors:  C K Atterwill; S J Bunn; D J Atkinson; S L Smith; D J Heal
Journal:  J Neural Transm       Date:  1984       Impact factor: 3.575

7.  The effect of tranquillizing drugs on the concentration of the sulphate ester of 4-hydroxy-3-methoxyphenylethane-1,2-diol in rat brain.

Authors:  T L Berridge; D F Sharman
Journal:  Br J Pharmacol       Date:  1974-01       Impact factor: 8.739

8.  Brain cortical tissue levels of noradrenaline and its glycol metabolites: effects of ischemia and postischemic administration of idazoxan.

Authors:  I Gustafson; A Lidén; T Wieloch
Journal:  Exp Brain Res       Date:  1992       Impact factor: 1.972

9.  Effect of a reversible and selective MAO-A inhibitor (cimoxatone) on diurnal variation in plasma prolactin level in man.

Authors:  M Strolin Benedetti; A Eschalier; A Lesage; G Dordain; V Rovei; E Zarifian; P Dostert
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

10.  Effect of low-dose lithium administration and subsequent withdrawal on biogenic amines in rat brain.

Authors:  P Ahluwalia; R L Singhal
Journal:  Br J Pharmacol       Date:  1980       Impact factor: 8.739
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