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Literature DB >> 4403369

Receptors for histamine can be detected on the surface of selected leukocytes.

K L Melmon, H R Bourne, J Weinstein, M Sela.

Abstract

Histamine insolubilized by chemical linkage via a protein or polypeptide carrier to Sepharose beads cannot penetrate cells. Even so, the resultant histamine-coated Sepharose binds leukocytes selectively. Despite the low molecular weight of histaminie, the binding is via preformed cell membrane receptors and can be specifically and competitively blocked or reversed by antihistamines.

Entities: Chemical

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Year: 1972 PMID： 4403369 DOI： 10.1126/science.177.4050.707

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

21 in total

1. Properties of a subpopulation of T cells bearing histamine receptors.

Authors: M Plaut; L M Lichtenstein; C S Henney
Journal: J Clin Invest Date: 1975-04 Impact factor: 14.808

2. Binding of histamine- and other ligand-conjugated macromolecules to lymphocytes.

Authors: G E Matthyssens; E Hurwitz; D Givol; M Sela
Journal: Mol Cell Biochem Date: 1975-05-30 Impact factor: 3.396

3. Histamine receptors on guinea-pig alveolar macrophages: chemical specificity and the effects of H1- and H2-receptor agonists and antagonists.

Authors: P Diaz; D G Jones; A B Kay
Journal: Clin Exp Immunol Date: 1979-03 Impact factor: 4.330

Receptors for histamine can be detected on the surface of selected leukocytes.

1. Properties of a subpopulation of T cells bearing histamine receptors.

2. Binding of histamine- and other ligand-conjugated macromolecules to lymphocytes.

3. Histamine receptors on guinea-pig alveolar macrophages: chemical specificity and the effects of H1- and H2-receptor agonists and antagonists.

4. Classification and biological distribution of histamine receptor sub-types.

5. Histamine-receptor leucocytes (HRL). Organ and lymphoid subpopulation distribution in man.

6. Leukocytes as secretory organs of inflammation.

7. Classification and biological distribution of histamine receptor sub-types. 1975.

8. Analysis of 3H-histamine interaction with lymphocytes: receptor binding or uptake?

9. Modulation of cellular-immune responses in vivo and in vitro by histamine receptor-bearing lymphocytes.

10. Identification of histamine-receptor leukocytes in the bovine.