Literature DB >> 440327

Cis-platinum(II) diamine dichloride causes mutation, transformation, and sister-chromatid exchanges in cultured mammalian cells.

D Turnbull, N C Popescu, J A DiPaolo, B C Myhr.   

Abstract

The anti-tumor agent cis-platinum(II) diamine dichloride caused dose-dependent toxicity in V79 Chinese hamster cells and in secondary Syrian hamster embryo cells. Chromosome aberrations were induced and positive dose--response relationships were observed for induction of sister-chromatid exchanges and 6-thioguanine-resistant mutations in V79 cells and morphologic transformation of secondary Syrian hamster embryo cells. The findings suggest that this chemical is a potential human carcinogen.

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Year:  1979        PMID： 440327     DOI： 10.1016/0165-1218(79)90088-0

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  7 in total

Review 1.  Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing.

Authors:  E Gebhart
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

2.  Cytogenetical tests on mammalian cells in vitro.

Authors:  J Moutschen
Journal:  Arch Toxicol       Date:  1980-11       Impact factor: 5.153

3.  The frequencies of micronuclei induced by cisplatin in newborn rat astrocytes are increased by 50-Hz, 7.5- and 10-mT electromagnetic fields.

Authors:  Yuichi Miyakoshi; Hayato Yoshioka; Yoshimitsu Toyama; Yuji Suzuki; Hidesuke Shimizu
Journal:  Environ Health Prev Med       Date:  2005-05       Impact factor: 3.674

4.  In vitro assessment of the toxicity of metal compounds : II. Mutagenesis.

Authors:  J D Heck; M Costa
Journal:  Biol Trace Elem Res       Date:  1982-12       Impact factor: 3.738

Review 5.  Effects of metals in in vitro bioassays.

Authors:  M A Sirover
Journal:  Environ Health Perspect       Date:  1981-08       Impact factor: 9.031

Review 6.  Role of cobalt, iron, lead, manganese, mercury, platinum, selenium, and titanium in carcinogenesis.

Authors:  G Kazantzis
Journal:  Environ Health Perspect       Date:  1981-08       Impact factor: 9.031

7.  Sister chromatid exchanges induced by two radiosensitizing platinum compounds (cis-dichloro-bis isopropylamine trans dihydroxy platinum IV (CHIP) and cis platinum metronidazole2Cl2(FLAP)) in CHO cells in vitro.

Authors:  E Bocian; M Laverick; A H Nias
Journal:  Br J Cancer       Date:  1983-12       Impact factor: 7.640
  7 in total

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