Literature DB >> 4402537

Photoreduction of NADP + sensitized by synthetic pigment systems.

E Greenbaum, R H Austin, H Frauenfelder, I C Gunsalus.   

Abstract

Two synthetic pigment systems capable of enzymatically photoreducing NADP(+) are described. One system contains proflavine; the other, acridine. The complete system consists of ethylene diamine tetraacetic acid (EDTA), proflavine (or acridine), ferredoxin-NADP reductase (EC 1.6.99.4), and NADP(+). The two pigments initiate the photoreduction of NADP(+) in different portions of the electromagnetic spectrum. Proflavine photosensitizes in the visible portion; acridine, in the ultraviolet. Neither proflavine nor acridine is structurally related to chlorophyll. The acridine system has the attractive property that the enzyme, ferredoxin-NADP reductase, is the only component of the system that absorbs appreciably in the visible region of the spectrum.

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Year:  1972        PMID： 4402537      PMCID： PMC426680          DOI： 10.1073/pnas.69.5.1273

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  5 in total

1.  PHOTOREDUCTION OF NAD AND NADP BY CHLOROPHYLLIN A IN THE PRESENCE OF ASCORBATE: REQUIREMENT FOR NADP REDUCTASE.

Authors:  L P VERNON; A S PIETRO; D A LIMBACH
Journal:  Arch Biochem Biophys       Date:  1965-01       Impact factor: 4.013

2.  Mixed function oxidation. IV. An induced methylene hydroxylase in camphor oxidation.

Authors:  J Hedegaard; I C Gunsalus
Journal:  J Biol Chem       Date:  1965-10       Impact factor: 5.157

3.  On the existence of spectrally distinct classes of flavoprotein semiquinones. A new method for the quantitative production of flavoprotein semiquinones.

Authors:  V Massey; G Palmer
Journal:  Biochemistry       Date:  1966-10       Impact factor: 3.162

4.  A soluble cytochrome P-450 functional in methylene hydroxylation.

Authors:  M Katagiri; B N Ganguli; I C Gunsalus
Journal:  J Biol Chem       Date:  1968-06-25       Impact factor: 5.157

5.  Crystalline cytochrome P-450cam.

Authors:  C Yu; I C Gunsalus
Journal:  Biochem Biophys Res Commun       Date:  1970-09-30       Impact factor: 3.575
  5 in total
  3 in total

1.  A thermodynamic model of regulation: modulation of redox equilibria in camphor monoxygenase.

Authors:  S G Sligar; I C Gunsalus
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

2.  Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics.

Authors:  Yojiro Anzai; Shengying Li; Mani Raj Chaulagain; Kenji Kinoshita; Fumio Kato; John Montgomery; David H Sherman
Journal:  Chem Biol       Date:  2008-09-22

3.  A role of the putidaredoxin COOH-terminus in P-450cam (cytochrome m) hydroxylations.

Authors:  S G Sligar; P G Debrunner; J D Lipscomb; M J Namtvedt; I C Gunsalus
Journal:  Proc Natl Acad Sci U S A       Date:  1974-10       Impact factor: 11.205
  3 in total

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