Literature DB >> 4402535

Activation of leukemia viruses by graft-versus-host and mixed lymphocyte reactions in vitro.

M S Hirsch, S M Phillips, C Solnik, P H Black, R S Schwartz, C B Carpenter.   

Abstract

Spleen cells from BALB/c or CAF(1) mice released little or no detectable leukemia virus when cultured 2-7 days in vitro. In contrast, spleen cells of CAF(1) mice previously inoculated with parental BALB/c spleen cells released leukemia viruses in 10 of 11 cases studied. Cultures of a mixture of spleen cells from normal BALB/c and CAF(1) mice also contained leukemia viruses. Phytohemagglutinin induced the transformation of lymphocytes in cultures of CAF(1) or BALB/c spleen cells, but this transformation did not activate leukemia viruses. It is concluded that mixed lymphocyte cultures in vitro, just as graft-versus-host reactions in vivo, can activate leukemia viruses that are normally present in a repressed form. This activation is not solely a function of lymphocyte transformation. The activated mouse leukemia virus may subsequently account for the observed high incidence of neoplasia in graft-versus-host disease.

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Year:  1972        PMID： 4402535      PMCID： PMC426630          DOI： 10.1073/pnas.69.5.1069

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  Electron microscopic studies of radiation-induced leukemia in mice: virus release following total-body x-ray irradiation.

Authors:  L Gross; D G Feldman
Journal:  Cancer Res       Date:  1968-09       Impact factor: 12.701

2.  Mixed culture cytopathogenicity: a new test for growth of murine leukemia viruses in tissue culture.

Authors:  V Klement; W P Rowe; J W Hartley; W E Pugh
Journal:  Proc Natl Acad Sci U S A       Date:  1969-07       Impact factor: 11.205

Review 3.  On the natural history of the murine leukemias: presidential address.

Authors:  H S Kaplan
Journal:  Cancer Res       Date:  1967-08       Impact factor: 12.701

4.  Lymphocyte in vitro cytotoxicity: mechanisms of immune and non-immune small lymphocyte mediated target L cell destruction.

Authors:  G A Granger; W P Kolb
Journal:  J Immunol       Date:  1968-07       Impact factor: 5.422

5.  One-way stimulation in mixed leukocyte cultures.

Authors:  F H Bach; N K Voynow
Journal:  Science       Date:  1966-07-29       Impact factor: 47.728

6.  A factor stimulating DNA synthesis derived from the medium of leukocyte cultures.

Authors:  S Kasakura; L Lowenstein
Journal:  Nature       Date:  1965-11-20       Impact factor: 49.962

7.  Leukemogenic activity of centrifugates from irradiated mouse thymus and bone marrow.

Authors:  N Haran-Ghera
Journal:  Int J Cancer       Date:  1966-01       Impact factor: 7.396

8.  Isolation of naturally occurring viruses of the murine leukemia virus group in tissue culture.

Authors:  J W Hartley; W P Rowe; W I Capps; R J Huebner
Journal:  J Virol       Date:  1969-02       Impact factor: 5.103

9.  Quantitative studies on the mixed lymphocyte interaction in rats. 3. Kinetics of the response.

Authors:  D B Wilson; P C Blyth JL NOWELL
Journal:  J Exp Med       Date:  1968-11-01       Impact factor: 14.307

10.  Chronic allogeneic disease. I. Development of glomerulonephritis.

Authors:  R M Lewis; M Y Armstrong; J André-Schwartz; A Muftuoglu; L Beldotti; R S Schwartz
Journal:  J Exp Med       Date:  1968-10-01       Impact factor: 14.307
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  38 in total

1.  Identification of a full-length cDNA for an endogenous retrovirus of miniature swine.

Authors:  D E Akiyoshi; M Denaro; H Zhu; J L Greenstein; P Banerjee; J A Fishman
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

2.  Expression of endogenous viral antigens during immune response.

Authors:  E Wecker
Journal:  Med Microbiol Immunol       Date:  1977       Impact factor: 3.402

3.  Secondary in vitro responses of T lymphocytes to non-H-2 alloantigens self-H-2-restricted responses induced in heterologous serum are not dependent on primary-stimulating non-H-2 alloantigens.

Authors:  A B Peck; L C Andersson; H Wigzell
Journal:  J Exp Med       Date:  1977-04-01       Impact factor: 14.307

4.  T-cell-induced expression of human immunodeficiency virus in macrophages.

Authors:  R D Schrier; J A McCutchan; J C Venable; J A Nelson; C A Wiley
Journal:  J Virol       Date:  1990-07       Impact factor: 5.103

5.  Spontaneous induction of endogenous murine leukemia virus-related antigen expression during short-term in vitro incubation of mouse lymphocytes.

Authors:  P Lonai; A Declève; H S Kaplan
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

Review 6.  Expression and detection of endogenous mouse C-type RNA viruses.

Authors:  D R Lowy; N M Teich; S K Chattopadhyay
Journal:  In Vitro       Date:  1974 Nov-Dec

7.  Abortive growth of human lymphocytes carrying a dormant Epstein-Barr viral genome.

Authors:  T Aya; T Osato
Journal:  Med Microbiol Immunol       Date:  1978       Impact factor: 3.402

8.  Expression of endogenous retroviral glycoprotein 70 by antigen-activated cytotoxic and suppressor T lymphocytes of nice.

Authors:  D Klenner; I Horak; A Schimpl; E Wecker
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

9.  Viruses and lymphocytes in rheumatoid arthritis. I. Studies on cultured rheumatoid lymphocytes.

Authors:  M Norval; H Hart; B P Marmion
Journal:  Ann Rheum Dis       Date:  1979-12       Impact factor: 19.103

10.  Mason-Pfizer like virus in kidney grafted patients.

Authors:  L Thiry; S Sprecher-Goldberger; P Vandenbussche; M Bossens; P Vereerstraten; O Hestermans-Medard
Journal:  Med Microbiol Immunol       Date:  1979-01-24       Impact factor: 3.402
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