| Literature DB >> 4402068 |
W Levin, A H Conney, A P Alvares, I Merkatz, A Kappas.
Abstract
Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[alpha]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[alpha]anthracene, a two- to fivefold increase in activity of benzo[alpha]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.Entities:
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Year: 1972 PMID： 4402068 DOI： 10.1126/science.176.4033.419
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728