Literature DB >> 4400526

Evidence for the presence of -adrenoceptors in the central thermoregulatory mechanism of rabbits.

B N Dhawan, P R Dua.   

Abstract

1. The effects of intracerebroventricular administration of some alpha- and beta-adrenoceptor stimulants and antagonists on the body temperature of rabbits were investigated.2. Noradrenaline produced a dose dependent rise in body temperature. Other catecholamines were less active.3. The noradrenaline response was blocked by alpha-adrenoceptor blocking agents while beta-adrenoceptor antagonists had no effect.4. alpha-Methyl-noradrenaline and metaraminol had some hyperthermic effect, but significantly reduced the response of noradrenaline.5. The possible presence of alpha-adrenoceptors in the central thermoregulatory mechanisms is suggested.

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Year:  1971        PMID： 4400526      PMCID： PMC1665782          DOI： 10.1111/j.1476-5381.1971.tb07180.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  16 in total

1.  EFFECTS ON TEMPERATURE OF AMINES INJECTED INTO THE CEREBRAL VENTRICLES. A NEW CONCEPT OF TEMPERATURE REGULATION.

Authors:  W FELDBERG; R D MYERS
Journal:  J Physiol       Date:  1964-09       Impact factor: 5.182

2.  A NEW CONCEPT OF TEMPERATURE REGULATION BY AMINES IN THE HYPOTHALAMUS.

Authors:  W FELDBERG; R D MYERS
Journal:  Nature       Date:  1963-12-28       Impact factor: 49.962

3.  ADRENERGIC MECHANISMS IN RABBIT OLFACTORY BULB.

Authors:  G C SALMOIRAGHI; F E BLOOM; E COSTA
Journal:  Am J Physiol       Date:  1964-12

4.  CHANGES IN TEMPERATURE PRODUCED BY MICRO-INJECTIONS OF AMINES INTO THE ANTERIOR HYPOTHALAMUS OF CATS.

Authors:  W FELDBERG; R D MYERS
Journal:  J Physiol       Date:  1965-03       Impact factor: 5.182

5.  A hypothesis for the mode of action of alpha-methyldopa in relieving hypertension.

Authors:  M D DAY; M J RAND
Journal:  J Pharm Pharmacol       Date:  1963-04       Impact factor: 3.765

6.  Antibody response in rabbits following injection of sheep erythrocytes into lateral ventricle of brain.

Authors:  B D JANKOVIC; M DRASKOCI; K ISAKOVIC
Journal:  Nature       Date:  1961-07-15       Impact factor: 49.962

7.  Facilitation of the flexor reflex in the cat by intrathecal injection of catecholamines.

Authors:  B N Dhawan; J N Sharma
Journal:  Br J Pharmacol       Date:  1970-10       Impact factor: 8.739

8.  Agonistic and antagonistic effects of alpha-methylnoradrenaline at central receptors.

Authors:  R J Boakes; J M Candy; J H Wolstencroft
Journal:  Brain Res       Date:  1968-11       Impact factor: 3.252

9.  A possible role played by central monoamine neurones in thermo-regulation.

Authors:  H Corrodi; K Fuxe; T Hökfelt
Journal:  Acta Physiol Scand       Date:  1967 Oct-Nov

10.  Effects of intraventricular and intrahypothalamic injection of noradrenaline and 5-HT on body temperature in conscious rabbits.

Authors:  K E Cooper; W I Cranston; A J Honour
Journal:  J Physiol       Date:  1965-12       Impact factor: 5.182
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  7 in total

1.  Catecholaminergic alpha-receptors and shivering in the rat.

Authors:  H W Marshall; H B Stoner
Journal:  J Physiol       Date:  1979-07       Impact factor: 5.182

2.  Alteration of shivering threshold in cold- and warm-adapted guinea pigs following intrahypothalamic injections of noradrenaline and of an adrenergic alpha-receptor blocking agent.

Authors:  E Zeisberger; K Brück
Journal:  Pflugers Arch       Date:  1976-03-30       Impact factor: 3.657

3.  Relation between the thermoregulatory effects of intracerebroventricularly injected dopamine and 5-hydroxytryptamine in the rabbit.

Authors:  T A de Roij; J Frens; M Vianen-Meijerink; F W Nijnanten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-01       Impact factor: 3.000

4.  Effects of catecholamines on thermoregulation in pigeons.

Authors:  N Chawla; M B Johri; P N Saxena; K C Singhal
Journal:  Br J Pharmacol       Date:  1974-08       Impact factor: 8.739

5.  The effect of intracerebroventricular administration of catecholamines and their antagonists on rectal temperature of Mastomys natalensis.

Authors:  R Shukla; R C Srimal; B N Dhawan
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-12       Impact factor: 3.000

6.  Comparison of the thermoregulatory responses to intracerebroventricularly injected dopamine and noradrenaline in the sheep.

Authors:  T A de Roij; J Bligh; C A Smith; J Frens
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-07       Impact factor: 3.000

7.  Increase in hepatic microsomal lipid peroxidation mediated by alpha-adrenergic system under cold stress and noradrenaline treatment.

Authors:  B S Sekhar; C K Kurup; T Ramasarma
Journal:  Mol Cell Biochem       Date:  1990-04-18       Impact factor: 3.396
  7 in total

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