| Literature DB >> 43981 |
A J Kastin, R D Olson, R H Ehrensing, M C Berzas, A V Schally, D H Coy.
Abstract
The effects of MIF-I (Pro-Leu-Gly-NH2) were examined in three experimental conditions in which the opiate antagonist naloxone is active. MIF-I was found to block the analgesic effects of enkephalins and also morphine in the tail-flick test but not in the vas deferens assay. Unlike naloxone, MIF-I did not seem to reduce food intake in VMH-lesioned rats. The results suggest the possibility that MIF-I may represent a class of naturally occurring opiate antagonists with varying activities in independent situations.Entities:
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Year: 1979 PMID： 43981 DOI： 10.1016/0091-3057(79)90270-3
Source DB: PubMed Journal: Pharmacol Biochem Behav ISSN： 0091-3057 Impact factor: 3.533