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Literature DB >> 4397172

Cardiovascular reactivity in the experimental hypertensive rat.

Abstract

1. In pithed preparations, deoxycorticosterone (DOCA)/NaCl-induced hypertensive rats showed increased cardiovascular reactivity to injected noradrenaline, DMPP, tyramine, angiotensin and to sympathetic nerve stimulation.2. Pithed, chronic renal hypertensive rats showed similar hyperreactivity to noradrenaline, DMPP and tyramine but responses to sympathetic nerve stimulation were within normal limits.3. In the isolated, Krebs perfused mesentery preparation, vessels obtained from both DOCA/NaCl and renal hypertensive rats showed hyperreactivity to injected noradrenaline. Responses to periarterial nerve stimulation were also markedly increased in preparations from DOCA/NaCl hypertensive rats, while preparations from renal hypertensive rats showed this effect only at higher rates of stimulation (12 and 25 Hz).

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Year: 1971 PMID： 4397172 PMCID： PMC1666997 DOI： 10.1111/j.1476-5381.1971.tb07086.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

32 in total

1. Effects of 6-hydroxydopamine on the perfused rat mesentery preparation.

Authors: L Finch; G D Leach
Journal: J Pharm Pharmacol Date: 1970-07 Impact factor: 3.765

2. Adrenergic mechanisms in hypertension.

Authors: M J Davey; H Reinert
Journal: Br J Pharmacol Date: 1968-09 Impact factor: 8.739

3. Pre- and postjunctional supersensitivity of the mesenteric artery preparation from normotensive and hypertensive rats.

Authors: G Haeusler; W Haefely
Journal: Naunyn Schmiedebergs Arch Pharmakol Date: 1970

4. Cardiovascular reactivity in rats with spontaneous inherited hypertension and constricted renal artery hypertension.

Authors: E L Phelan
Journal: Am Heart J Date: 1966-01 Impact factor: 4.749

5. Vascular hyper-reactivity with sodium loading and with deoxycorticosterone induced hypertension in the rat.

Authors: L J Beilin; D N Wade
Journal: Nature Date: 1970-09-12 Impact factor: 49.962

6. Reactivity to norepinephrine and nature of the alpha adrenergic receptor in vascular smooth muscle of a genetically hypertensive rat.

Authors: B V Clineschmidt; R G Geller; W C Govier; A Sjoerdsma
Journal: Eur J Pharmacol Date: 1970-04 Impact factor: 4.432

10. [Differences between tyramine and dimethylphenylpiperazine in the Ca++-dependency and in the temporary course of noradrenaline release from the isolated rabbit heart].

Authors: R Lindmar; K Löffelholz; E Muscholl
Journal: Experientia Date: 1967-11-15

6 in total

1. Proceedings: An increased reactivity in hypertensive animals after prolonged antihypertensive therapy.

Authors: L Finch
Journal: Br J Pharmacol Date: 1974-11 Impact factor: 8.739

2. Depressor responses to spinal stimulation in the pithed rat.

Authors: G J Dusting; M J Rand
Journal: Br J Pharmacol Date: 1972-06 Impact factor: 8.739

3. Distribution of cardiac output and nutritional blood flow in the unanesthetized rat: alterations during experimental renal hypertension.

Authors: A M Bralet; J Wepierre; J Bralet
Journal: Pflugers Arch Date: 1973-10-22 Impact factor: 3.657

Cardiovascular reactivity in the experimental hypertensive rat.

1. Effects of 6-hydroxydopamine on the perfused rat mesentery preparation.

2. Adrenergic mechanisms in hypertension.

3. Pre- and postjunctional supersensitivity of the mesenteric artery preparation from normotensive and hypertensive rats.

4. Cardiovascular reactivity in rats with spontaneous inherited hypertension and constricted renal artery hypertension.

5. Vascular hyper-reactivity with sodium loading and with deoxycorticosterone induced hypertension in the rat.

6. Reactivity to norepinephrine and nature of the alpha adrenergic receptor in vascular smooth muscle of a genetically hypertensive rat.

7. Disposition of norepinephrine and epinephrine in vascular tissue, determined by the technique of oil immersion.

8. Synthesis and turnover of norepinephrine in the heart of the spontaneously hypertensive rat.

9. Turnover and synthesis of norepinephrine in experimental hypertension in rats.

10. [Differences between tyramine and dimethylphenylpiperazine in the Ca++-dependency and in the temporary course of noradrenaline release from the isolated rabbit heart].

1. Proceedings: An increased reactivity in hypertensive animals after prolonged antihypertensive therapy.

2. Depressor responses to spinal stimulation in the pithed rat.

3. Distribution of cardiac output and nutritional blood flow in the unanesthetized rat: alterations during experimental renal hypertension.

4. Central adrenergic neurones and the initiation and development of experimental hypertension.

5. An increased reactivity in hypertensive rats unaffected by prolonged antihypertensive therapy.

6. Acidaemia produced by spinal stimulation in the pithed rat.