Literature DB >> 439105

A rapid, sensitive technique to assay penicillamine levels in blood and urine.

A S Russell, R Saetre, P Davis, D L Rabenstein.   

Abstract

We have used a rapid, sensitive technique to assay penicillamine and its disulphide metabolites in body fluids. Penicillamine in serum is rapidly oxidized and the serum levels of the reduced material found in a pilot study of 10 patients ranged between 0.07 to 0.28 mg%. This technique may prove useful in allowing closer monitoring of therapy with this agent.

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Year:  1979        PMID: 439105

Source DB:  PubMed          Journal:  J Rheumatol        ISSN: 0315-162X            Impact factor:   4.666


  6 in total

1.  D-penicillamine metabolism: the role of transformation in blood plasma.

Authors:  D A Joyce; B R Murphy
Journal:  Agents Actions       Date:  1990-11

2.  Serum SH reactivity: a simple assessment of D-penicillamine absorption?

Authors:  N D Hall; D R Blake; G J Alexander; C Vaisey; P A Bacon
Journal:  Rheumatol Int       Date:  1981       Impact factor: 2.631

Review 3.  Clinical pharmacokinetics of D-penicillamine.

Authors:  P Netter; B Bannwarth; P Péré; A Nicolas
Journal:  Clin Pharmacokinet       Date:  1987-11       Impact factor: 6.447

4.  The pharmacokinetics of penicillamine in a female mongrel dog.

Authors:  R F Bergstrom; R D Kay; J G Wagner
Journal:  J Pharmacokinet Biopharm       Date:  1981-10

Review 5.  Penicillamine in rheumatoid arthritis. A problem of toxicity.

Authors:  H G Taylor; A Samanta
Journal:  Drug Saf       Date:  1992 Jan-Feb       Impact factor: 5.606

6.  D-penicillamine metabolism in an in-vivo model of inflamed synovium.

Authors:  D A Joyce; M J Forrest; P M Brooks
Journal:  Agents Actions       Date:  1988-12
  6 in total

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