Literature DB >> 4390986

Natural immunity to bacterial infections: the relation of complement to heat-labile opsonins.

M R Smith, H S Shin, W B Wood.   

Abstract

Heat-labile opsonins to pneumococci in normal mammalian sera, unlike antibodies, fail to interact with the bacteria at 0 degrees C and require Ca(++) and/or Mg(++). They are readily removed from serum by antigen-antibody complexes that fix complement (C) and are inhibited by reagents that inactivate various C components. The principal heat-labile opsonin to pneumococci is activated C3 (C3(b)), but a slight enhancing effect is exerted by one or more of the late-reacting components of the hemolytic complement system (C5-C9). Since heat-labile opsonins are immunologically polyspecific, they presumably play a broad protective role in the early (preantibody) phase of acute bacterial infections.

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Year:  1969        PMID： 4390986      PMCID： PMC223442          DOI： 10.1073/pnas.63.4.1151

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  GENETIC TRANSFORMATION AMONG LIVING PNEUMOCOCCI IN THE MOUSE.

Authors:  E OTTOLENGHI; C M MACLEOD
Journal:  Proc Natl Acad Sci U S A       Date:  1963-09       Impact factor: 11.205

2.  STUDIES ON HEAT-LABILE OPSONIN IN RABBIT SERUM.

Authors:  J G HIRSCH; B STRAUSS
Journal:  J Immunol       Date:  1964-01       Impact factor: 5.422

3.  THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

Authors:  F C GREENWOOD; W M HUNTER; J S GLOVER
Journal:  Biochem J       Date:  1963-10       Impact factor: 3.857

4.  A gene locus concerned with hemolytic complement in Mus musculus.

Authors:  L A HERZENBERG; D K TACHIBANA; L A HERZENBERG; L T ROSENBERG
Journal:  Genetics       Date:  1963-05       Impact factor: 4.562

5.  Human monocytes: distinct receptor sites for the third component of complement and for immunoglobulin G.

Authors:  H Huber; M J Polley; W D Linscott; H H Fudenberg; H J Müller-Eberhard
Journal:  Science       Date:  1968-12-13       Impact factor: 47.728

6.  The third component of the guinea pig complement system. I. Purification and characterization.

Authors:  H S Shin; M M Mayer
Journal:  Biochemistry       Date:  1968-08       Impact factor: 3.162

7.  Multiple nature of the third component of guinea-pig complement. I. Separation and characterization of three factors a, b, and c, essential for haemolysis.

Authors:  P G Klein; H J Wellensiek
Journal:  Immunology       Date:  1965-06       Impact factor: 7.397

8.  Methods for the separation, purification and measurement of nine components of hemolytic complement in guinea-pig serum.

Authors:  R A Nelson; J Jensen; I Gigli; N Tamura
Journal:  Immunochemistry       Date:  1966-03

9.  Surface phagocytosis; further evidence of its destructive action upon fully encapsulated pneumococci in the absence of type-specific antibody.

Authors:  M R SMITH; W B WOOD
Journal:  J Exp Med       Date:  1958-01-01       Impact factor: 14.307

10.  Receptors for complement of leukocytes.

Authors:  W H Lay; V Nussenzweig
Journal:  J Exp Med       Date:  1968-11-01       Impact factor: 14.307
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  9 in total

1.  Quantitation of the third component of human complement attached to the surface of opsonized bacteria: opsonin-deficient sera and phagocytosis-resistant strains.

Authors:  H A Verbrugh; W C van Dijk; M E van Erne; R Peters; P K Peterson; J Verhoef
Journal:  Infect Immun       Date:  1979-12       Impact factor: 3.441

2.  The virulence for mice of strains of Escherichia coli related to the effects of K antigens on their resistance to phagocytosis and killing by complement.

Authors:  C J Howard; A A Glynn
Journal:  Immunology       Date:  1971-05       Impact factor: 7.397

3.  [The importance of serum components, particularly complement factors, properdin and transferrin, in inhibition of bacterial growth by human serum (author's transl)].

Authors:  M Fürbeth; D Adam
Journal:  Infection       Date:  1976       Impact factor: 3.553

Review 4.  Bacteria, toxins, and the peritoneum.

Authors:  T Hau
Journal:  World J Surg       Date:  1990 Mar-Apr       Impact factor: 3.352

5.  Interactions of Pseudomonas aeruginosa with immunoglobulins and complement in sputum.

Authors:  S Hann; D S Holsclaw
Journal:  Infect Immun       Date:  1976-07       Impact factor: 3.441

6.  Protective role of smooth lipopolysaccharide in the serum bactericidal reaction.

Authors:  B L Reynolds; H Pruul
Journal:  Infect Immun       Date:  1971-12       Impact factor: 3.441

7.  Efficacy of antimicrobial therapy in experimental rat pneumonia: effects of impaired phagocytosis.

Authors:  I A Bakker-Woudenberg; J Y de Jong-Hoenderop; M F Michel
Journal:  Infect Immun       Date:  1979-07       Impact factor: 3.441

8.  A versatile assay to determine bacterial and host factors contributing to opsonophagocytotic killing in hirudin-anticoagulated whole blood.

Authors:  Erika van der Maten; Marien I de Jonge; Ronald de Groot; Michiel van der Flier; Jeroen D Langereis
Journal:  Sci Rep       Date:  2017-02-08       Impact factor: 4.379

9.  Differential effects of serum heat treatment on chemotaxis and phagocytosis by human neutrophils.

Authors:  Alexander R Mankovich; Cheng-Yuk Lee; Volkmar Heinrich
Journal:  PLoS One       Date:  2013-01-22       Impact factor: 3.240
  9 in total

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