Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Immobilization of intramembrane charge in Myxicola giant axons.

Literature DB >> 439022

Immobilization of intramembrane charge in Myxicola giant axons.

Abstract

1. Immobilization of gating charge was examined in Myxicola giant axons dialysed with Cs+. 2. With increasing pulse durations the ratio QOFF/QON decreases to as little as 0.25 with a time constant of 3.2 msec determined from composite data. Na inactivation time constants measured in the same axons ranged from 0.8 to 1.5 msec. A slow component of QOFF tends to appear as QOFF/QON decreases. 3. Both QON and QOFF may be decreased by a prepulse with no change in their time course. In this case the time course of the decrease is similar to that observed for INA. 4. The normalized steady-state charge immobilization curve is shifted in the depolarized direction by 15--20 mV from the normalized Na inactivation curve.

Entities: Chemical

Mesh：

Substances：
Sodium

Year: 1979 PMID： 439022 PMCID： PMC1281563 DOI： 10.1113/jphysiol.1979.sp012611

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

13 in total

1. The temporal and steady-state relationships between activation of the sodium conductance and movement of the gating particles in the squid giant axon.

Authors: R D Keynes; E Rojas
Journal: J Physiol Date: 1976-02 Impact factor: 5.182

3. Solvent substitution as a probe of channel gating in Myxicola. Differential effects of D2O on some components of membrane conductance.

Authors: C L Schauf; J O Bullock
Journal: Biophys J Date: 1980-05 Impact factor: 4.033

Immobilization of intramembrane charge in Myxicola giant axons.

1. The temporal and steady-state relationships between activation of the sodium conductance and movement of the gating particles in the squid giant axon.

2. Inactivation of the asymmetrical displacement current in giant axons of Loligo forbesi.

3. Characteristics of sodium tail currents in Myxicola axons. Comparison with membrane asymmetry currents.

4. Gating currents of the sodium channels: three ways to block them.

5. Combined voltage-clamp and dialysis of Myxicola axons: behaviour of membrane asymmetry currents.

6. Inactivation of the sodium channel. II. Gating current experiments.

7. Rate constants associated with changes in sodium conductance in axons perfused with sodium fluoride.

8. Evidence for two types of sodium conductance in axons perfused with sodium fluoride solution.

9. Inactivation of the sodium channel. I. Sodium current experiments.

10. Charge movement associated with the opening and closing of the activation gates of the Na channels.

1. Gating current kinetics in Myxicola giant axons. Order of the back transition rate constants.

2. Internal cesium and the sodium inactivation gate in Myxicola giant axons.

3. Solvent substitution as a probe of channel gating in Myxicola. Differential effects of D2O on some components of membrane conductance.

4. Gating currents in th intact crayfish giant axon.

5. Experimental evidence consistent with aggregation kinetics in the sodium current of Myxicola giant axons.

6. Evidence for negative gating charges in Myxicola axons.

7. Inactivation in Myxicola giant axons responsible for slow and accumulative adaptation phenomena.

8. Modifications of sodium channel gating in Myxicola giant axons by deuterium oxide, temperature, and internal cations.

9. Gallamine triethiodide-induced modifications of sodium conductance in Myxicola giant axons.

10. Voltage-dependent effect of a scorpion toxin on sodium current inactivation.