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Literature DB >> 4390208

A negative correlation between oxygen uptake and glutathione oxidation in rat liver homogenates.

Abstract

GSH added to rat liver homogenates inhibited respiration and increased GSSG formation approximately proportionally to the amount of GSH added; the effect was increased by added magnesium chloride. Added NADPH and citrate decreased GSSG formation and increased respiration; 6.0mm-nicotinamide prevented GSSG formation and increased respiration. There was a negative correlation between GSSG formation and oxygen uptake. It is suggested that the decrease in oxygen uptake is mainly due to GSSG concentration and also that in vivo a GSH-GSSG steady state occurs.

Entities: Chemical Species

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Year: 1969 PMID： 4390208 PMCID： PMC1184788 DOI： 10.1042/bj1140005

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

23 in total

1. [INHIBITORY EFFECT OF CYSTEAMINE ON THE OXYGEN CONSUMPTION OF THE CHICK EMBRYONAL INTESTINE IN ORGAN TYPE CULTURE].

Authors: J M KIRRMANN
Journal: C R Hebd Seances Acad Sci Date: 1964-04-27

2. LIPID ALTERATIONS OCCURRING IN MICROSOMES DURING THE ENZYMIC OXIDATION OF TPNH.

Authors: H E MAY; J L POYER; P B MCCAY
Journal: Biochem Biophys Res Commun Date: 1965-04-09 Impact factor: 3.575

3. [ACTION OF CYSTAMINE AND CYSTEAMINE ON THE OXYGEN CONSUMPTION AND COUPLED OXYDATIVE PHOSPHORYLATION OF THE LIVER MITOCHONDRIA OF RATS].

Authors: P LELIEVRE
Journal: Int J Radiat Biol Relat Stud Phys Chem Med Date: 1965

4. The nature of the sex-linked differences in glutathione peroxidase activity and aerobic oxidation of glutathione in male and female rat liver.

Authors: R E Pinto; W Bartley
Journal: Biochem J Date: 1969-11 Impact factor: 3.857

4 in total

A negative correlation between oxygen uptake and glutathione oxidation in rat liver homogenates.

1. [INHIBITORY EFFECT OF CYSTEAMINE ON THE OXYGEN CONSUMPTION OF THE CHICK EMBRYONAL INTESTINE IN ORGAN TYPE CULTURE].

2. LIPID ALTERATIONS OCCURRING IN MICROSOMES DURING THE ENZYMIC OXIDATION OF TPNH.

3. [ACTION OF CYSTAMINE AND CYSTEAMINE ON THE OXYGEN CONSUMPTION AND COUPLED OXYDATIVE PHOSPHORYLATION OF THE LIVER MITOCHONDRIA OF RATS].

4. Swelling and lysis of rat liver mitochondria induced by ferrous ions.

5. Determination of the reduced and oxidized pyridine nucleotides in animal tissues.

6. Chain elongation of linoleic acid and its inhibition by other fatty acids in vitro.

7. Effect of cysteine on respiration and catalyse synthesis by Saccharomyces cerevisiae.

8. THE EFFECT OF DISULPHIDES ON MITOCHONDRIAL OXIDATIONS.

9. The inhibitory effect of reduced glutathione on the lipid peroxidation of the microsomal fraction and mitochondria.

10. Oxidation of reduced glutathione by subcellular fractions of rat liver.

1. Amino acid production in isolated rat liver mitochondria.

Review 2. [Glutathione peroxidase: enzymology and biological aspects].

3. Liver glutathione and glutathione reductase response of endotoxin-treated mice.

4. The nature of the sex-linked differences in glutathione peroxidase activity and aerobic oxidation of glutathione in male and female rat liver.