Literature DB >> 4386718

Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding.

C S Lieber, L M DeCarli.   

Abstract

Hepatic microsomes contain an ethanol-oxidizing system distinct from alcohol dehydrogenase. In vitro, it has characteristics comparable to those of microsomal drug-detoxifying enzymes and, in vivo, it is capable of adaptation to the administration of ethanol. The existence of this microsomal ethanol-oxidizing system may explain ultrastructural, pharmacological, and biochemical effects of ethanol.

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Year:  1968        PMID： 4386718     DOI： 10.1126/science.162.3856.917

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  56 in total

Review 1.  The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine.

Authors:  Hermann M Bolt; Peter H Roos; Ricarda Thier
Journal:  Int Arch Occup Environ Health       Date:  2003-03-01       Impact factor: 3.015

Review 2.  Nitric oxide and redox regulation in the liver: Part I. General considerations and redox biology in hepatitis.

Authors:  Diana L Diesen; Paul C Kuo
Journal:  J Surg Res       Date:  2009-10-09       Impact factor: 2.192

3.  The effect of ethanol on drug oxidations in vitro and the significance of ethanol-cytochrome P-450 interaction.

Authors:  D L Cinti; R Grundin; S Orrenius
Journal:  Biochem J       Date:  1973-06       Impact factor: 3.857

4.  Histological changes in the liver and indices of drug metabolism in alcoholics.

Authors:  E A Sotaniemi; J Ahlqvist; R O Pelkonen; H Pirttiaho; P V Luoma
Journal:  Eur J Clin Pharmacol       Date:  1977-04-20       Impact factor: 2.953

Review 5.  Interaction of alcohol with other drugs and nutrients. Implication for the therapy of alcoholic liver disease.

Authors:  C S Lieber
Journal:  Drugs       Date:  1990       Impact factor: 9.546

6.  Rapid fatty acid ethyl ester synthesis by porcine myocardium upon ethanol infusion into the left anterior descending coronary artery.

Authors:  Danita M Yoerger; Catherine A Best; Brendan M McQuillan; Gregory E Supple; J Luis Guererro; Joanne E Cluette-Brown; Ali Hasaba; Michael H Picard; James R Stone; Michael Laposata
Journal:  Am J Pathol       Date:  2006-05       Impact factor: 4.307

7.  Alcoholic liver disease: a synopsis of the Charles Lieber's Memorial Symposia 2009-2012.

Authors:  Manuela G Neuman; Lawrence Cohen; Samir Zakhari; Radu M Nanau; Sebastian Mueller; Michelle Schneider; Charles Parry; Romina Isip; Helmut K Seitz
Journal:  Alcohol Alcohol       Date:  2014-05-09       Impact factor: 2.826

8.  Studies on the metabolic activation of diethanolnitrosamine in animal-mediated and in vitro assays using Escherichia coli K-12 343/113 as an indicator.

Authors:  S Knasmüller; G Stehlik; G Mohn
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

9.  Serum activity and hepatic localization of superoxide dismutase in alcoholics.

Authors:  T Inagaki; S Takiya; K Ikuta; T Sasaki; K Kato; A Shimizu; M Suzuki; K Kato
Journal:  Gastroenterol Jpn       Date:  1989-06

10.  Ethanol oxidizing enzyme activites in liver disease.

Authors:  J Dow; N Krasner; A Goldberg
Journal:  Br J Clin Pharmacol       Date:  1976-06       Impact factor: 4.335
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