Literature DB >> 4377108

Product inhibition studies on bovine liver carbamoyl phosphate synthetase.

K R Elliott, K F Tipton.   

Abstract

A study of the product-inhibition patterns of carbamoyl phosphate synthetase from bovine liver is reported. Inhibition by adenosine, AMP and inorganic ions is also reported. The results are in agreement with the previously proposed model in which the order of substrate binding is ATPMg, followed by HCO(3) (-), ATPMg and NH(4) (+). The order of product release on the basis of the reported results is carbamoyl phosphate, followed by ADPMg, ADPMg and inorganic phosphate.

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Year:  1974        PMID： 4377108      PMCID： PMC1168187          DOI： 10.1042/bj1410817

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  13 in total

1.  A KINETIC STUDY OF CARBAMYL PHOSPHATE SYNTHETASE.

Authors:  L A FAHIEN; P P COHEN
Journal:  J Biol Chem       Date:  1964-06       Impact factor: 5.157

2.  THE EFFECT OF IONIC STRENGTH ON REACTIONS CATALYZED BY CARBAMYLPHOSPHATE SYNTHETASE.

Authors:  J KENNEDY; S GRISOLIA
Journal:  Biochim Biophys Acta       Date:  1965-01

3.  Purification of carbamyl phosphate synthetase from frog liver.

Authors:  M MARSHALL; R L METZENBERG; P P COHEN
Journal:  J Biol Chem       Date:  1958-07       Impact factor: 5.157

4.  Studies on the biosynthesis of carbamyl phosphate.

Authors:  R L METZENBERG; L M HALL; M MARSHALL; P P COHEN
Journal:  J Biol Chem       Date:  1957-12       Impact factor: 5.157

5.  The determination of enzyme inhibitor constants.

Authors:  M DIXON
Journal:  Biochem J       Date:  1953-08       Impact factor: 3.857

6.  A kinetic analysis of enzyme systems involving four substrates.

Authors:  K R Elliott; K F Tipton
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857

7.  Kinetic studies on rat liver carbamyl phosphate synthetase.

Authors:  L A Kerson; S H Appel
Journal:  J Biol Chem       Date:  1968-08-25       Impact factor: 5.157

8.  Structure and function of carbamoylphosphate synthetase. On the mechanism of bicarbonate activation.

Authors:  G Guthöhrlein; J Knappe
Journal:  Eur J Biochem       Date:  1969-03

9.  Modified determination of citrulline.

Authors:  G Guthöhrlein; J Knappe
Journal:  Anal Biochem       Date:  1968-10-10       Impact factor: 3.365

10.  Kinetic studies of bovine liver carbamoyl phosphate synthetase.

Authors:  K R Elliott; K F Tipton
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857
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  5 in total

1.  Metabolism of citrulline in man.

Authors:  D Rabier; P Kamoun
Journal:  Amino Acids       Date:  1995-12       Impact factor: 3.520

2.  Novel mechanism for carbamoyl-phosphate synthetase: a nucleotide switch for functionally equivalent domains.

Authors:  M Kothe; B Eroglu; H Mazza; H Samudera; S Powers-Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1997-11-11       Impact factor: 11.205

3.  A kinetic analysis of enzyme systems involving four substrates.

Authors:  K R Elliott; K F Tipton
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857

4.  Leigh-Like Syndrome Due to Homoplasmic m.8993T>G Variant with Hypocitrullinemia and Unusual Biochemical Features Suggestive of Multiple Carboxylase Deficiency (MCD).

Authors:  Shanti Balasubramaniam; B Lewis; D M Mock; H M Said; M Tarailo-Graovac; A Mattman; C D van Karnebeek; D R Thorburn; R J Rodenburg; J Christodoulou
Journal:  JIMD Rep       Date:  2016-07-22

5.  Kinetic studies of bovine liver carbamoyl phosphate synthetase.

Authors:  K R Elliott; K F Tipton
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857
  5 in total

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