Literature DB >> 4375983

The existence of an electrophilic component in the reaction catalysed by triose phosphate isomerase.

M R Webb, J R Knowles.   

Abstract

In the presence of triose phosphate isomerase, the substrate dihydroxyacetone phosphate is reduced stereoselectively by NaBH(4). The reduction of enzyme-bound substrate is almost completely or completely stereoselective and occurs about one order of magnitude faster than that in free solution. This acceleration implies a polarization of the carbonyl group when dihydroxyacetone phosphate is bound.

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Year:  1974        PMID： 4375983      PMCID： PMC1168116          DOI： 10.1042/bj1410589

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  6 in total

1.  Mechanism of C-H bond cleavage in aldolase and isomerase reactions.

Authors:  I A ROSE
Journal:  Brookhaven Symp Biol       Date:  1962-12

2.  Synthesis of phosphatides in isolated mitochondria. III. The enzymatic phosphorylation of glycerol.

Authors:  C BUBLITZ; E P KENNEDY
Journal:  J Biol Chem       Date:  1954-12       Impact factor: 5.157

3.  The active chemical state of D-glyceraldehyde 3-phosphate in its reactions with D-glyceraldehyde 3-phosphate dehydrogenase, aldolase and triose phosphate isomerase.

Authors:  D R Trentham; C H McMurray; C I Pogson
Journal:  Biochem J       Date:  1969-08       Impact factor: 3.857

4.  Dihydroxyacetone phosphate. Its structure and reactivity with -glycerophosphate dehydrogenase, aldolase and triose phosphate isomerase and some possible metabolic implications.

Authors:  S J Reynolds; D W Yates; C I Pogson
Journal:  Biochem J       Date:  1971-04       Impact factor: 3.857

5.  Active-site labelling of triose phosphate isomerase. The reaction of bromohydroxyacetone phosphate with a unique glutamic acid residue and the migration of the label to tyrosine.

Authors:  S De la Mare; A F Coulson; J R Knowles; J D Priddle; R E Offord
Journal:  Biochem J       Date:  1972-09       Impact factor: 3.857

6.  Specificity and kinetics of triose phosphate isomerase from chicken muscle.

Authors:  S J Putman; A F Coulson; I R Farley; B Riddleston; J R Knowles
Journal:  Biochem J       Date:  1972-09       Impact factor: 3.857
  6 in total
  2 in total

Review 1.  Infra-red and Raman spectroscopic studies of enzyme structure and function.

Authors:  C W Wharton
Journal:  Biochem J       Date:  1986-01-01       Impact factor: 3.857

2.  Active site of triosephosphate isomerase: in vitro mutagenesis and characterization of an altered enzyme.

Authors:  D Straus; R Raines; E Kawashima; J R Knowles; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205
  2 in total

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