Literature DB >> 4375470

Regulation of hepatic lipogenesis by plasma free fatty acids: simultaneous studies on lipoprotein secretion, cholesterol synthesis, ketogenesis and gluconeogenesis.

P A Mayes, D L Topping.   

Abstract

1. An inverse logarithmic relationship was found between lipogenesis and the concentration of serum free fatty acids perfusing the rat liver. 2. Increased concentrations of serum free fatty acids did not alter cholesterol synthesis, triglyceride secretion or increase gluconeogenesis. 3. No direct relationship was found between ketogenesis and either lipogenesis or gluconeogenesis.

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Year:  1974        PMID: 4375470      PMCID: PMC1167977          DOI: 10.1042/bj1400111

Source DB:  PubMed          Journal:  Biochem J        ISSN: 0264-6021            Impact factor:   3.857


  20 in total

1.  Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver.

Authors:  J R Williamson; R A Kreisberg; P W Felts
Journal:  Proc Natl Acad Sci U S A       Date:  1966-07       Impact factor: 11.205

2.  Inhibition of enzyme activities by free fatty acids.

Authors:  S V Pande; J F Mead
Journal:  J Biol Chem       Date:  1968-12-10       Impact factor: 5.157

3.  The effect of palmityl coenzyme A on pigeon liver fatty acid synthetase.

Authors:  J A Dorsey; J W Porter
Journal:  J Biol Chem       Date:  1968-06-25       Impact factor: 5.157

4.  Effect of (-)-hydroxycitrate on fatty acid synthesis by rat liver in vivo.

Authors:  J M Lowenstein
Journal:  J Biol Chem       Date:  1971-02-10       Impact factor: 5.157

5.  The regulation of ketogenesis from octanoic acid. The role of the tricarboxylic acid cycle and fatty acid synthesis.

Authors:  J D McGarry; D W Foster
Journal:  J Biol Chem       Date:  1971-02-25       Impact factor: 5.157

6.  Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused livers of rats.

Authors:  J H Exton; C R Park
Journal:  J Biol Chem       Date:  1967-06-10       Impact factor: 5.157

7.  Perfusion in situ with tritium oxide to measure hepatic lipogenesis and lipid secretion. Normal and orotic acid-fed rats.

Authors:  H G Windmueller; A E Spaeth
Journal:  J Biol Chem       Date:  1966-06-25       Impact factor: 5.157

8.  De novo synthesis of fatty acid in perfused rat liver as a determinant of plasma lipoprotein production.

Authors:  H G Windmueller; A E Spaeth
Journal:  Arch Biochem Biophys       Date:  1967-11       Impact factor: 4.013

9.  Effects of palmitoyl CoA on citrate and malate transport by rat liver mitochondria.

Authors:  M L Halperin; B H Robinson; I B Fritz
Journal:  Proc Natl Acad Sci U S A       Date:  1972-04       Impact factor: 11.205

10.  Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liver.

Authors:  D H Williamson; M W Bates; H A Krebs
Journal:  Biochem J       Date:  1968-07       Impact factor: 3.857

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  15 in total

1.  Effect of prolonged ethanol ingestion on hepatic lipogenesis and related enzyme activities.

Authors:  M J Savolainen; J K Hiltunen; I E Hassinen
Journal:  Biochem J       Date:  1977-04-15       Impact factor: 3.857

2.  Measurement of the rates of acetyl-CoA hydrolysis and synthesis from acetate in rat hepatocytes and the role of these fluxes in substrate cycling.

Authors:  B Crabtree; M J Gordon; S L Christie
Journal:  Biochem J       Date:  1990-08-15       Impact factor: 3.857

3.  Evidence that the production of acetate in rat hepatocytes is a predominantly cytoplasmic process.

Authors:  B Crabtree; M J Souter; S E Anderson
Journal:  Biochem J       Date:  1989-02-01       Impact factor: 3.857

4.  Fatty acid synthesis in the perfused liver of adrenalectomized rats.

Authors:  C J Kirk; T R Verrinder; D A Hems
Journal:  Biochem J       Date:  1976-06-15       Impact factor: 3.857

5.  Stimulation of triacylglycerol synthesis in rat adipocytes by plasma very-low-density lipoproteins.

Authors:  P Thomopoulos; M Berthelier; D Lagrange; M J Chapman; M H Laudat
Journal:  Biochem J       Date:  1978-10-15       Impact factor: 3.857

6.  Fatty acid synthesis in the regenerating liver of the rat.

Authors:  C D Gove; D A Hems
Journal:  Biochem J       Date:  1978-01-15       Impact factor: 3.857

7.  Control of glucose metabolism in isolated acini of the lactating mamary gland of the rat. Effects of oleate on glucose utilization and lipogenesis.

Authors:  A M Robinson; D H Williamson
Journal:  Biochem J       Date:  1978-03-15       Impact factor: 3.857

8.  Acute effects of ethanol on the perfused rat liver. Studies on lipid and carbohydrate metabolism, substrate cycling and perfusate amino acids.

Authors:  D L Topping; D G Clark; G B Storer; R P Trimble; R J Illman
Journal:  Biochem J       Date:  1979-10-15       Impact factor: 3.857

9.  Synthesis of fatty acids in the perused mouse liver.

Authors:  D M Salmon; N L Bowen; D A Hems
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857

10.  Lipogenesis in rat brown adipocytes. Effects of insulin and noradrenaline, contributions from glucose and lactate as precursors and comparisons with white adipocytes.

Authors:  E D Saggerson; T W McAllister; H S Baht
Journal:  Biochem J       Date:  1988-05-01       Impact factor: 3.857

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