Literature DB >> 4374943

Effects of alpha-amanitin on the stimulation of prostatic ribonucleic acid polymerase by prostatic steroid-protein receptor complexes.

P Davies, K Griffiths.   

Abstract

Stimulation of prostatic RNA polymerase in vitro by prostatic 17beta-hydroxy-5alpha-androstan-3-one (5alpha-dihydrotestosterone)-receptor complexes has been previously reported. By use of the selective inhibitor, alpha-amanitin, we have shown that both nucleolar and extranucleolar RNA polymerase activities may be stimulated, but stimulation is abolished at high ionic strength.

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Year:  1974        PMID： 4374943      PMCID： PMC1168038          DOI： 10.1042/bj1400565

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

1.  Alpha-amanitin: a specific inhibitor of one of two DNA-pendent RNA polymerase activities from calf thymus.

Authors:  C Kedinger; M Gniazdowski; J L Mandel; F Gissinger; P Chambon
Journal:  Biochem Biophys Res Commun       Date:  1970-01-06       Impact factor: 3.575

2.  Specific inhibition of nuclear RNA polymerase II by alpha-amanitin.

Authors:  T J Lindell; F Weinberg; P W Morris; R G Roeder; W J Rutter
Journal:  Science       Date:  1970-10-23       Impact factor: 47.728

3.  Effects of oestradiol, -amanitin and ionic strength on the in vitro synthesis of RNA by uterus nuclei.

Authors:  C Raynaud-Jammet; F Biéri; E E Baulieu
Journal:  Biochim Biophys Acta       Date:  1971-10-14

4.  Effects of dihydrotestosterone on the synthesis of nucleic acid and ATP in prostatic nuclei.

Authors:  N Bashirelahi; G J Chader; C A Villee
Journal:  Biochem Biophys Res Commun       Date:  1969-12-04       Impact factor: 3.575

5.  Different responses of soluble whole nuclear RNA polymerase and soluble nucleolar RNA polymerase to divalent cations and to inhibition by alpha-amanitin.

Authors:  S T Jacob; E M Sajdel; H N Munro
Journal:  Biochem Biophys Res Commun       Date:  1970-02-20       Impact factor: 3.575

6.  Androgen receptors. Steroid- and tissue-specific retention of a 17 beta-hydroxy-5 alpha-androstan-3-one-protein complex by the cell nuclei of ventral prostate.

Authors:  S Fang; S Liao
Journal:  J Biol Chem       Date:  1971-01-10       Impact factor: 5.157

7.  Rapid effect of testosterone on ribonucleic acid polymerase activity of rat ventral prostate.

Authors:  S Liao; K R Leininger; D Sagher; R W Barton
Journal:  Endocrinology       Date:  1965-10       Impact factor: 4.736

8.  Studies on the pathogenesis of liver necrosis by alpha-amanitin. Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver nuclei.

Authors:  F Stirpe; L Fiume
Journal:  Biochem J       Date:  1967-11       Impact factor: 3.857

9.  Experimental conditions affecting ribonucleic acid polymerase in isolated rat liver nuclei. Effect of nucleoside triphosphate concentration, temperature, ammonium sulphate and heparin.

Authors:  F Novello; F Stirpe
Journal:  Biochem J       Date:  1969-05       Impact factor: 3.857

10.  Soluble complexes between steroid hormones and target-tissue receptors bind specifically to target-tissue chromatin.

Authors:  A W Steggles; T C Spelsberg; S R Glasser; B W O'Malley
Journal:  Proc Natl Acad Sci U S A       Date:  1971-07       Impact factor: 11.205
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  2 in total

1.  Initiation and elongation of polyribonucleotide chains on rat ventral-prostate chromatin transcribed by homologous ribonucleic acid polymerase B.

Authors:  P Thomas; P Davies; K Griffiths
Journal:  Biochem J       Date:  1977-08-15       Impact factor: 3.857

2.  Androgenic regulation of elongation of polyribonucleotide chains on rat ventral-prostate chromatin.

Authors:  P Thomas; P Davies; K Griffiths
Journal:  Biochem J       Date:  1978-02-15       Impact factor: 3.857
  2 in total

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