| Literature DB >> 43743 |
J Wilting, M M Weideman, A C Roomer, J H Perrin.
Abstract
The molar ellipticity of the warfarin-albumin complex at 310 nm increases with pH from 6 to 9. This pH dependence runs parallel with that of the molar ellipticity of the albumin alone at 292 nm. The change in molar ellipicity with pH occurs in a smaller pH interval after addition of the physiological concentration of calcium ions. These findings give support to the assumption that the binding site for warfarin on the albumin molecule is affected by the neutral-to-base transition in the protein.Entities:
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Year: 1979 PMID： 43743 DOI： 10.1016/0005-2795(79)90075-8
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002