Literature DB >> 4372990

Anti-anabolic effects of adenosine 3':5'-cyclic monophosphate. Inhibition of protein synthesis.

A Sellers, D P Bloxham, K A Munday, M Akhtar.   

Abstract

1. Evidence is presented that cyclic AMP inhibits the incorporation of l-[4,5-(3)H]leucine into protein in a cell-free system from rat liver. This inhibition occurs after aminoacyl-tRNA formation. 2. Microsomal fractions, isolated after the incubation of postmitochondrial supernatant with cyclic AMP and ATP, show a diminished ability to synthesize protein. Both cyclic AMP and ATP are required for this effect. 3. A possible physiological role for the anti-anabolic action of cyclic AMP is discussed in terms of the control of gluconeogenesis.

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Year:  1974        PMID： 4372990      PMCID： PMC1166218          DOI： 10.1042/bj1380335

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  22 in total

1.  Studies on carbohydrate metabolism in rat liver slices. IV. Biochemical sequence of events after insulin administration.

Authors:  A E RENOLD; A B HASTINGS; F B NESBETT; J ASHMORE
Journal:  J Biol Chem       Date:  1955-03       Impact factor: 5.157

2.  Respiratory granules of heart muscle.

Authors:  K W CLELAND; E C SLATER
Journal:  Biochem J       Date:  1953-03       Impact factor: 3.857

3.  Evidence for regulatin of cholesterol and fatty acid synthesis in liver by cyclic adenosine 3',5'-monophosphate.

Authors:  L A Bricker; G S Levey
Journal:  J Biol Chem       Date:  1972-08-10       Impact factor: 5.157

4.  Studies on the inhibition of amino acid incorporation into protein by isolated rat liver ribosomes by protein kinase.

Authors:  D Monier; K Santhanam; S R Wagle
Journal:  Biochem Biophys Res Commun       Date:  1972-03-10       Impact factor: 3.575

5.  Studies on the control of cholesterol biosynthesis: the adenosine 3':5'-cyclic monophosphate-dependent accumulation of a steroid carboxylic acid.

Authors:  D P Bloxham; M Akhtar
Journal:  Biochem J       Date:  1971-06       Impact factor: 3.857

Review 6.  The hormonal control of hepatic gluconeogenesis.

Authors:  J H Exton; L E Mallette; L S Jefferson; E H Wong; N Friedmann; T B Miller; C R Park
Journal:  Recent Prog Horm Res       Date:  1970

7.  Control of gluconeogenesis from amino acids in the perfused rat liver.

Authors:  L E Mallet; J H Exton; C R Park
Journal:  J Biol Chem       Date:  1969-10-25       Impact factor: 5.157

8.  Effects of glucagon on amino acid transport and utilization in the perfused rat liver.

Authors:  L E Mallette; J H Exton
Journal:  J Biol Chem       Date:  1969-10-25       Impact factor: 5.157

9.  Role of adenosine 3',5'-monophosphate in the effects of insulin and anti-insulin serum on liver metabolism.

Authors:  L S Jefferson; J H Exton; R W Butcher; E W Sutherland; C R Park
Journal:  J Biol Chem       Date:  1968-03-10       Impact factor: 5.157

10.  The effect of chemical agents on the turnover of the bound phosphate associated with the sodium-and-potassium ion-stimulated adenosine triphosphatase in ox brain microsomes.

Authors:  R Rodnight
Journal:  Biochem J       Date:  1970-11       Impact factor: 3.857
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  3 in total

1.  Enhancement of the anti-anabolic response to adenosine 3':5'-cyclic monophosphate during development. The inhibition of hepatic protein synthesis.

Authors:  A Klaipongpan; D P Bloxham; M Akhtar
Journal:  Biochem J       Date:  1977-11-15       Impact factor: 3.857

2.  Growth hormone, cyclic nucleotides and the rapid control of translation in heart muscle.

Authors:  J Mowbray; J A Davies; D J Bates; C J Jones
Journal:  Biochem J       Date:  1975-12       Impact factor: 3.857

3.  Mechanism of translational control by hemin in reticulocyte lysates.

Authors:  A Datta; C de Haro; J M Sierra; S Ochoa
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205
  3 in total

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