Literature DB >> 437048

Penetration of oximes across the blood-brain barrier. A histochemical study of the cerebral cholinesterases reactivation.

I S De la Manche, D E Vergé, C Bouchaud, H Coq, H Sentenac-Roumanou.   

Abstract

The comparison of the effects of 4 oximes upon the cerebral cholinesterases reactivation after intoxication with paraoxon shows that the best results are obtained with toxogonine and 1574 [(carbaldoxime-4 pyridinium)-1(methyl-1 imidazolium-3)-3 propane]. The reactivation power of this latter compound seems due to the ease with which it can pass through the blood-brain barrier.

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Year:  1979        PMID： 437048     DOI： 10.1007/bf01922752

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  4 in total

1.  [COMPARATIVE STUDIES ON THE POSSIBILITY OF PENETRATION OF SOME ESTERASE-ACTIVATING OXIMES INTO THE CENTRAL NERVOUS SYSTEM].

Authors:  W D ERDMANN
Journal:  Arzneimittelforschung       Date:  1965-02

2.  The histochemical localization of cholinesterases in the central nervous system of the rat.

Authors:  G B KOELLE
Journal:  J Comp Neurol       Date:  1954-02       Impact factor: 3.215

3.  A histochemical method for localizing cholinesterase activity.

Authors:  G B KOELLE; J A FRIEDENWALD
Journal:  Proc Soc Exp Biol Med       Date:  1949-04

4.  The reactivation by pyridium aldoximes of phosphorylated acetylcholinesterase in the central nervous system.

Authors:  F Hobbiger; V Vojvodić
Journal:  Biochem Pharmacol       Date:  1967-03       Impact factor: 5.858
  4 in total
  2 in total

1.  Forensic significance of acetylcholine esterase histochemistry in organophosphate intoxication. Original investigations and review of the literature.

Authors:  M Oehmichen; K Besserer
Journal:  Z Rechtsmed       Date:  1982

2.  Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice.

Authors:  J G Clement; A S Hansen; C A Boulet
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153
  2 in total

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