Literature DB >> 436998

The morphology of microtubules in incubated synaptosomes. Effect of low temperature and vinblastine.

F Hajós, A Csillag, M Kálmán.   

Abstract

A time-dependent rise in the percentage of microtubule-containing synaptosomes was observed reaching a 41--47% peak after 30 min incubation at room temperature (22--25 degrees C) in a saline medium. Fixation at low temperature or incubation with vinblastine decreased markedly the number of synpatosomes containing microtubules. It was concluded that incubation with cations and processing at room temperature were prerequisites of optimal preservation of synaptosomal microtubules. Their spatial orientation relative to the synaptic cleft was deduced from statistical examination of profiles in different orientations.

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Year:  1979        PMID： 436998     DOI： 10.1007/bf00236622

Source DB:  PubMed          Journal:  Exp Brain Res        ISSN： 0014-4819            Impact factor:   1.972


  13 in total

1.  The subcellular distribution of colchicine-binding protein ('microtubule protein') in rat brain.

Authors:  J R. Lagnado; C Lyons; G Wickremasinghe
Journal:  FEBS Lett       Date:  1971-06-24       Impact factor: 4.124

2.  An improved method for the preparation of synaptosomal fractions in high purity.

Authors:  F Hajós
Journal:  Brain Res       Date:  1975-08-15       Impact factor: 3.252

3.  Structural changes in vitro of isolated nerve endings. I. Effect of cations.

Authors:  F Hajós; A Csillag
Journal:  Brain Res       Date:  1976-08-06       Impact factor: 3.252

4.  Isolation of synaptic plasma membrane from brain by combined flotation-sedimentation density gradient centrifugation.

Authors:  D H Jones; A I Matus
Journal:  Biochim Biophys Acta       Date:  1974-08-09

5.  Actomyosin-like protein isolated from mammalian brain.

Authors:  S Puszkin; S Berl; E Puszkin; D D Clarke
Journal:  Science       Date:  1968-07-12       Impact factor: 47.728

6.  Muscle-like contractile proteins and tubulin in synaptosomes.

Authors:  A L Blitz; R E Fine
Journal:  Proc Natl Acad Sci U S A       Date:  1974-11       Impact factor: 11.205

Review 7.  Synaptic morphology in the normal and degenerating nervous system.

Authors:  E G Gray; R W Guillery
Journal:  Int Rev Cytol       Date:  1966

8.  Experimental alterations of neurofilaments and neurotubules by calcium and other ions.

Authors:  W W Schlaepfer
Journal:  Exp Cell Res       Date:  1971-07       Impact factor: 3.905

9.  An association between mitochondria and microtubules in synaptosomes and axon terminals of cerebral cortex.

Authors:  K Y Chan; A H Bunt
Journal:  J Neurocytol       Date:  1978-04

10.  An ultrastructural examination of the action of vinblastine on microtubules, neurofilaments and muscle filaments in vitro.

Authors:  D R Tomlinson; T Bennett
Journal:  Cell Tissue Res       Date:  1976-02-25       Impact factor: 5.249
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  3 in total

1.  Two pools of electron cytochemically demonstrable adenylate cyclase activity in cortical synaptosomes.

Authors:  M A Rostomian; K S Abramian; M Kálmán; F Hajós
Journal:  Histochemistry       Date:  1983

2.  Ion-induced release of LHRH, TRH and alpha-MSH from hypothalamic synaptosomes and its inhibition by vinblastine.

Authors:  J Warberg; C R Parker; C Oliver; A Barnea; J C Porter
Journal:  Pflugers Arch       Date:  1980-05       Impact factor: 3.657

Review 3.  The Presynaptic Microtubule Cytoskeleton in Physiological and Pathological Conditions: Lessons from Drosophila Fragile X Syndrome and Hereditary Spastic Paraplegias.

Authors:  Felipe J Bodaleo; Christian Gonzalez-Billault
Journal:  Front Mol Neurosci       Date:  2016-07-25       Impact factor: 5.639
  3 in total

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