Literature DB >> 4369896

Cyclic guanosine monophosphate: elevation in degenerating photoreceptor cells of the C3H mouse retina.

D B Farber, R N Lolley.   

Abstract

As a result of an early deficiency in cyclic nucleotide phosphodiesterase activity, guanosine 3',5'-monophosphate accumulates in retinal photoreceptor cells before they begin to degenerate. It is suggested that degeneration of the photoreceptor cells is related to an imbalance in their metabolism or function which is caused by the elevated levels of cyclic guanosine monophosphate.

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Year:  1974        PMID： 4369896     DOI： 10.1126/science.186.4162.449

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  108 in total

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3.  The corneal ERG of the heterozygous retinal degeneration mouse.

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Review 10.  Photoreceptor cell death mechanisms in inherited retinal degeneration.

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