Literature DB >> 436839

Lipid composition of human malignant melanoma tumors at various levels of malignant growth.

J Portoukalian, G Zwingelstein, J F Doré.   

Abstract

The lipid pattern of thirteen human melanoma tumors from various tissues were investigated. In seven of the tumors, an estimate was given about the proportion of malignant melanocytes to the total cell population, and a reverse correlation was determined between the proportion of malignant cells in these tumors and their neutral lipid content. The phospholipids did not show any modification, nor did the cholesterol in the cancerous tissues. The ganglioside pattern was found to be similar in all analyzed samples, with GM3, GM2 and GD3 as major components, although no correlation was found between the malignant level and the ganglioside content of the tumors.

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Year:  1979        PMID： 436839     DOI： 10.1111/j.1432-1033.1979.tb12866.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  34 in total

1.  Induction of GM1a/GD1b synthase triggers complex ganglioside expression and alters neuroblastoma cell behavior; a new tumor cell model of ganglioside function.

Authors:  Lixian Dong; Yihui Liu; Anamaris M Colberg-Poley; Karen Kaucic; Stephan Ladisch
Journal:  Glycoconj J       Date:  2011-04-26       Impact factor: 2.916

2.  Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells.

Authors:  Haw-Young Kwon; Seok-Jo Kim; Cheorl-Ho Kim; Sung-Wook Son; Kyoung-Sook Kim; Jai-Heon Lee; Su-Il Do; Young-Choon Lee
Journal:  Exp Mol Med       Date:  2010-12-31       Impact factor: 8.718

3.  Recombinant AAV-mediated in vivo long-term expression and antitumour activity of an anti-ganglioside GM3(Neu5Gc) antibody.

Authors:  G M Piperno; A López-Requena; A Predonzani; D Dorvignit; M Labrada; L Zentilin; O R Burrone; M Cesco-Gaspere
Journal:  Gene Ther       Date:  2015-07-16       Impact factor: 5.250

4.  Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells.

Authors:  Kazunori Hamamura; Keiko Furukawa; Takanori Hayashi; Takeshi Hattori; Junji Nakano; Hideyuki Nakashima; Tetsuya Okuda; Hideki Mizutani; Hisashi Hattori; Minoru Ueda; Takeshi Urano; Kenneth O Lloyd; Koichi Furukawa
Journal:  Proc Natl Acad Sci U S A       Date:  2005-07-22       Impact factor: 11.205

5.  Ganglioside composition of the rat choriocarcinoma cell line, Rcho-1.

Authors:  T Shirai; S Itonori; T Tai; M J Soares; K Shiota; T Ogawa
Journal:  Glycoconj J       Date:  1996-06       Impact factor: 2.916

6.  A shift from N-glycolyl- to N-acetyl-sialic acid in the GM3 ganglioside impairs tumor development in mouse lymphocytic leukemia cells.

Authors:  Ana Victoria Casadesús; Yuniel Fernández-Marrero; Marilyn Clavell; José Alberto Gómez; Tays Hernández; Ernesto Moreno; Alejandro López-Requena
Journal:  Glycoconj J       Date:  2013-04-02       Impact factor: 2.916

7.  Metastatic melanoma secreted IL-10 down-regulates CD1 molecules on dendritic cells in metastatic tumor lesions.

Authors:  Gianni Gerlini; Adrian Tun-Kyi; Christa Dudli; Günter Burg; Nicola Pimpinelli; Frank O Nestle
Journal:  Am J Pathol       Date:  2004-12       Impact factor: 4.307

Review 8.  NGcGM3/VSSP vaccine as treatment for melanoma patients.

Authors:  Kirenia Pérez; Marta Osorio; Julio Hernández; Adriana Carr; Luis Enrique Fernández
Journal:  Hum Vaccin Immunother       Date:  2013-02-26       Impact factor: 3.452

9.  Identification of a human neuroectodermal tumor antigen (OFA-I-2) as ganglioside GD2.

Authors:  L D Cahan; R F Irie; R Singh; A Cassidenti; J C Paulson
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

10.  Antitumor effects of a novel monoclonal antibody with high binding affinity to ganglioside GD3.

Authors:  S Ohta; A Honda; Y Tokutake; H Yoshida; N Hanai
Journal:  Cancer Immunol Immunother       Date:  1993       Impact factor: 6.968
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