Literature DB >> 4366489

Genetic variation in coumarin hydroxylase activity in the mouse (Mus musculus).

A W Wood, A H Conney.   

Abstract

Basal and phenobarbital-induced rates of hepatic metabolism of coumarin to 7-hydroxycoumarin are markedly higher in DBA/2J mice than they are in the AKR/J, C57BL/6J, and C3H/HeJ strains. Intermediate coumarin hydroxylase activity in F(1) hybrids of mating between DBA/2J and the other three strains indicates an additive mode of inheritance.

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Year:  1974        PMID： 4366489     DOI： 10.1126/science.185.4151.612

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  11 in total

Review 1.  Multiple forms of inducible drug-metabolizing enzymes: a reasonable mechanism by which any organism can cope with adversity.

Authors:  D W Nebert
Journal:  Mol Cell Biochem       Date:  1979-09-28       Impact factor: 3.396

2.  Interindividual variability of coumarin 7-hydroxylation in a Turkish population.

Authors:  M Iscan; H Rostami; M Iscan; T Güray; O Pelkonen; A Rautio
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953

3.  Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.

Authors:  P Salonpää; K Krause; O Pelkonen; H Raunio
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-04       Impact factor: 3.000

4.  Coumarin 7-hydroxylase activity in human liver microsomes. Properties of the enzyme and interspecies comparisons.

Authors:  O Pelkonen; E A Sotaniemi; J T Ahokas
Journal:  Br J Clin Pharmacol       Date:  1985-01       Impact factor: 4.335

5.  Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.

Authors:  B Hahnemann; P Salonpää; M Pasanen; J Mäenpää; P Honkakoski; R Juvonen; M A Lang; O Pelkonen; H Raunio
Journal:  Biochem J       Date:  1992-08-15       Impact factor: 3.857

6.  Regulation of Cyp2a5 transcription in mouse primary hepatocytes: roles of hepatocyte nuclear factor 4 and nuclear factor I.

Authors:  Johanna Ulvila; Satu Arpiainen; Olavi Pelkonen; Kaoru Aida; Tatsuya Sueyoshi; Masahiko Negishi; Jukka Hakkola
Journal:  Biochem J       Date:  2004-08-01       Impact factor: 3.857

7.  Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases.

Authors:  P Pellinen; F Stenbäck; A Rautio; O Pelkonen; M Lang; M Pasanen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-10       Impact factor: 3.000

8.  Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity.

Authors:  J S Miles; A W McLaren; L M Forrester; M J Glancey; M A Lang; C R Wolf
Journal:  Biochem J       Date:  1990-04-15       Impact factor: 3.857

9.  Coumarin toxicity in different strains of mice.

Authors:  W Endell; G Seidel
Journal:  Agents Actions       Date:  1978-04

10.  Competitive inhibition of coumarin 7-hydroxylation by pilocarpine and its interaction with mouse CYP 2A5 and human CYP 2A6.

Authors:  T Kinonen; M Pasanen; J Gynther; A Poso; T Järvinen; E Alhava; R O Juvonen
Journal:  Br J Pharmacol       Date:  1995-11       Impact factor: 8.739
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