Literature DB >> 4365573

Enzyme activity in invasive tumors of human breast and colon.

H B Bosmann, T C Hall.   

Abstract

Elevated levels of glycoprotein:sialyltransferase activity (EC 2.4.99.1; CMP-N-acetylneuraminate: D-galactosyl-glycoprotein N-acetylneuraminyltransferase) were found in human malignant neoplastic tissues compared to normal, benign, and "preneoplastic" tissues. This increase was not due to the cell density of the tissue. Elevated levels of certain proteases and glycosidases were also found. The increase in transferase activity may be associated with altered membrane synthesis in the neoplastic state; changes in the activity of degradative enzymes may be associated with tumor invasiveness and maintenance of the neoplastic state. Measurements on human tumors are possibly more directly relevant to cancer than those described for transformed fibroblastic cells in vitro.

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Year:  1974        PMID： 4365573      PMCID： PMC388336          DOI： 10.1073/pnas.71.5.1833

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

1.  A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

Review 2.  Biochemical properties of normal and neoplastic cell surfaces; a review.

Authors:  P Emmelot
Journal:  Eur J Cancer       Date:  1973-05       Impact factor: 9.162

3.  Sialyl transferase activity in normal and RNA- and DNA-virus transformed cells utilizing desialyzed, trypsinized cell plasma membrane external surface glycoproteins as exogenous acceptors.

Authors:  H B Bosmann
Journal:  Biochem Biophys Res Commun       Date:  1972-12-04       Impact factor: 3.575

4.  Surface glycoproteins of normal and transformed cells: a difference determined by sialic acid and a growth-dependent sialyl transferase.

Authors:  L Warren; J P Fuhrer; C A Buck
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205

5.  Elevated glycosidases and proteolytic enzymes in cells transformed by RNA tumor virus.

Authors:  H B Bosmann
Journal:  Biochim Biophys Acta       Date:  1972-04-21

6.  Glycoprotein synthesis and degradation: glycoprotein: N-acetyl glucosamine transferase, proteolyticand glycosidase activity in normal and polyoma virus transformeBHK cells.

Authors:  H B Bosmann; G Z Pike
Journal:  Life Sci II       Date:  1970-12-22

7.  Release from density dependent growth inhibition by proteolytic enzymes.

Authors:  B M Sefton; H Rubin
Journal:  Nature       Date:  1970-08-22       Impact factor: 49.962

8.  Glycoprotein degradation. Glycosidases in fibroblasts transformed by oncogenic viruses.

Authors:  H B Bosmann
Journal:  Exp Cell Res       Date:  1969-02       Impact factor: 3.905

9.  Collagen-galactosyl transferase: subcellular localization and distribution in fibroblasts transformed by oncogenic viruses.

Authors:  H B Bosmann
Journal:  Life Sci       Date:  1969-07-15       Impact factor: 5.037

10.  Rat-liver-sialidase activity utilizing a tritium-labeled sialic-acid derivative of glycoprotein substrates. Activity in normal and hypothrombinemic rats.

Authors:  R J Bernacki; H B Bosmann
Journal:  Eur J Biochem       Date:  1973-05-02
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  43 in total

1.  Cancer-associated isoenzyme of serum galactosyltransferase.

Authors:  M M Weiser; D K Podolsky; K J Iselbacher
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

2.  Cell surface expression of 4 beta-galactosyltransferase accompanies rat parotid gland hypertrophy induced by changes in diet.

Authors:  M G Humphreys-Beher; C A Schneyer
Journal:  Biochem J       Date:  1987-09-01       Impact factor: 3.857

3.  Fibrinolytic activity associated with cultured human neoplastic and normal cells.

Authors:  K L Rosenthal; W A Tompkins; J T Wachsman
Journal:  Mol Cell Biochem       Date:  1977-04-12       Impact factor: 3.396

4.  Combretastatin A4-β-Galactosyl Conjugates for Ovarian Cancer Prodrug Monotherapy.

Authors:  Tomohiro Doura; Kazuaki Takahashi; Yasumitsu Ogra; Noriyuki Suzuki
Journal:  ACS Med Chem Lett       Date:  2017-01-20       Impact factor: 4.345

5.  [Elevated serum-sialyltransferase activity in human malignant diseases: a new diagnostic tool? (author's transl)].

Authors:  U Ganzinger; F Dorner; F M Unger; K Moser; K Jentzsch
Journal:  Klin Wochenschr       Date:  1977-06-01

6.  Differences in the isoelectric focusing patterns of gamma-glutamyl transpeptidase from normal and cancerous rat mammary tissue.

Authors:  S Jaken; M Mason
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

7.  Flow-regulated endothelial glycocalyx determines metastatic cancer cell activity.

Authors:  Solomon A Mensah; Alina A Nersesyan; Ian C Harding; Claire I Lee; Xuefei Tan; Selina Banerjee; Mark Niedre; Vladimir P Torchilin; Eno E Ebong
Journal:  FASEB J       Date:  2020-03-13       Impact factor: 5.191

Review 8.  Serum-sialyltransferase activity in cancer patients.

Authors:  P G Berge; A Wilhelm; H Schriewer; G Wüst
Journal:  Klin Wochenschr       Date:  1982-05-03

9.  Breast cancer markers: comparison between sialyltransferase and human mammary epithelial antigens (HME-Ags) for the detection of human breast tumors grafted in nude mice.

Authors:  M Sasaki; S Barber; R L Ceriani
Journal:  Breast Cancer Res Treat       Date:  1985       Impact factor: 4.872

10.  Sialyltransferase activity in tumor tissues.

Authors:  P G Berge; A Wilhelm; H Schriewer
Journal:  Klin Wochenschr       Date:  1984-04-02
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