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Literature DB >> 4364531

Viral DNA-RNA hybrids in cells infected with simian virus: the simian virus 40 transcriptional intermediates.

Abstract

Brief labeling of cells infected with simian virus 40 with tritiated uridine resulted in the incorporation of part of the label into material that was soluble in 1 M NaCl and sensitive to KOH, with a buoyant density close to that of DNA. The properties of this material suggest that it represents single-stranded nascent molecules of messenger RNA of simian virus 40 hydrogen-bonded over a small portion of their length to viral DNA templates. The name "simian virus 40 transcriptional intermediate molecules" is suggested for these naturally occurring DNA.RNA hybrid molecules. The DNA in the hybrid seems to be in the form of replicative intermediate molecules.

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Year: 1974 PMID： 4364531 PMCID： PMC388207 DOI： 10.1073/pnas.71.4.1267

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

32 in total

3. The control of SV40 transcription during a lytic infection: late RNA synthesis in the presence of inhibitors of DNA replication.

Authors: L J Rosenthal; M Brown
Journal: Nucleic Acids Res Date: 1977-03 Impact factor: 16.971

7. Characterization of simian virus 40 tsA58 transcriptional intermediates at restrictive temperatures: relationship between DNA replication and transcription.

Authors: E H Birkenmeier; E May; N P Salzman
Journal: J Virol Date: 1977-06 Impact factor: 5.103

7 in total

Viral DNA-RNA hybrids in cells infected with simian virus: the simian virus 40 transcriptional intermediates.

1. SV40 DNA strand selection by Escherichia coli RNA polymerase.

2. Molecular weight of poliovirus ribonucleic acid.

3. Regulation of transcription of the SV40 DNA in productively infected and in transformed cells.

4. The effect of actinomycin D on the transcription and replication of simian virus 40 deoxyribonucleic acid.

5. Selective extraction of polyoma DNA from infected mouse cell cultures.

6. Characterization of the simian virus 40-specific RNA in virus-yielding and transformed cells.

7. Enzyme induction in SV40-infected green monkey kidney cultures.

8. Participation of a DNA-RNA hybrid complex in in vivo genetic transcription.

9. A DNA-RNA complex as an intermediate of in vitro genetic transcription.

10. Polynucleotide ligase activity in cells infected with simian virus 40, polyoma virus, or vaccinia virus.

1. Regulation of simian virus 40 early and late gene transcription without viral DNA replication.

2. Topoisomerase I is associated with the regulatory region of transcriptionally active SV 40 minichromosomes.

3. The control of SV40 transcription during a lytic infection: late RNA synthesis in the presence of inhibitors of DNA replication.

4. Initiator RNA in discontinuous polyoma DNA synthesis.

5. Functions of gene C and gene D products of bacteriophage phi X 174.

6. Separation and properties of two kinds of simian virus 40 late transcription complexes.

7. Characterization of simian virus 40 tsA58 transcriptional intermediates at restrictive temperatures: relationship between DNA replication and transcription.