Literature DB >> 4360937

Absence of a specific ganglioside galactosyltransferase in mouse cells transformed by murine sarcoma virus.

P H Fishman, R O Brady, R M Bradley, S A Aaronson, G J Todaro.   

Abstract

The ganglioside composition of a nonproducer subclone (derived from BALB/c 3T3 mouseembryo cells) transformed by Kirsten murine sarcoma virus was drastically altered compared to the nontransformed parental clone. The transformed clone was unable to synthesize the mono- and disialogangliosides, G(M1) and G(D1a), due to the complete absence of a specific galactosyltransferase. The lack of this enzyme activity was established by sensitive radiochemical and enzymological techniques in vivo and in vitro.

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Year:  1974        PMID： 4360937      PMCID： PMC387990          DOI： 10.1073/pnas.71.2.298

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

1.  Transformation by rous sarcoma virus: effects on cellular glycolipids.

Authors:  S I Hakomori; T Saito; P K Vogt
Journal:  Virology       Date:  1971-06       Impact factor: 3.616

2.  A common biochemical change in SV40 and polyoma virus transformed mouse cells coupled to control of cell growth in culture.

Authors:  P T Mora; F A Cumar; R O Brady
Journal:  Virology       Date:  1971-10       Impact factor: 3.616

3.  Characterization of murine sarcoma virus (Kirsten) transformation of mouse and human cells.

Authors:  S A Aaronson; C A Weaver
Journal:  J Gen Virol       Date:  1971-11       Impact factor: 3.891

4.  Gas chromatographic determination of gangliosides in mouse cell lines and in virally transformed derivative lines.

Authors:  I Dijong; P T Mora; R O Brady
Journal:  Biochemistry       Date:  1971-10-26       Impact factor: 3.162

5.  Enhanced glycolipid: -galactosyltransferase activity in contact-inhibited hamster cells, and loss of this response in polyoma transformants.

Authors:  S Kijimoto; S Hakomori
Journal:  Biochem Biophys Res Commun       Date:  1971-08-06       Impact factor: 3.575

6.  Glycosyltransferase activities in normal and polyoma-transformed BHK cells.

Authors:  H Den; A M Schultz; M Basu; S Roseman
Journal:  J Biol Chem       Date:  1971-04-25       Impact factor: 5.157

7.  Nonproducer clones of murine sarcoma virus transformed BALB-3T3 cells.

Authors:  S A Aaronson; S P Rowe
Journal:  Virology       Date:  1970-09       Impact factor: 3.616

8.  The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion.

Authors:  S Roseman
Journal:  Chem Phys Lipids       Date:  1970-10       Impact factor: 3.329

9.  Enzymatic block in the synthesis of gangliosides in DNA virus-transformed tumorigenic mouse cell lines.

Authors:  F A Cumar; R O Brady; E H Kolodny; V W McFarland; P T Mora
Journal:  Proc Natl Acad Sci U S A       Date:  1970-10       Impact factor: 11.205

10.  Antigenic properties of murine sarcoma virus-transformed BALB-3T3 nonproducer cells.

Authors:  J R Stephenson; S A Aaronson
Journal:  J Exp Med       Date:  1972-03-01       Impact factor: 14.307
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  16 in total

1.  Correlation between enzyme activity and substrate storage in a cell culture model system for Gaucher disease.

Authors:  U H Schueler; T Kolter; C R Kaneski; G C Zirzow; K Sandhoff; R O Brady
Journal:  J Inherit Metab Dis       Date:  2004       Impact factor: 4.982

2.  Functional incorporation of ganglioside into intact cells: induction of choleragen responsiveness.

Authors:  J Moss; P H Fishman; V C Manganiello; M Vaughan; R O Brady
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

3.  Cholera toxin interactions with thyrotropin receptors on thyroid plasma membranes.

Authors:  B R Mullin; S M Aloj; P H Fishman; G Lee; L D Kohn; R O Brady
Journal:  Proc Natl Acad Sci U S A       Date:  1976-05       Impact factor: 11.205

4.  Use of brefeldin A to define sites of glycosphingolipid synthesis: GA2/GM2/GD2 synthase is trans to the brefeldin A block.

Authors:  W W Young; M S Lutz; S E Mills; S Lechler-Osborn
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

5.  Thyrotropin-ganglioside interactions and their relationship to the structure and function of thyrotropin receptors.

Authors:  B R Mullin; P H Fishman; G Lee; S M Aloj; F D Ledley; R J Winand; L D Kohn; R O Brady
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

6.  Characterization of Lewis antigens in normal colon and gastrointestinal adenocarcinomas.

Authors:  M Blaszczyk; K Y Pak; M Herlyn; H F Sears; Z Steplewski
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

7.  Ganglioside inhibition of fibronectin-mediated cell adhesion to collagen.

Authors:  H K Kleinman; G R Martin; P H Fishman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

8.  Alteration of glycolipids in ras-transfected NIH 3T3 cells.

Authors:  G R Matyas; S A Aaronson; R O Brady; P H Fishman
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205

9.  Altered metabolism and cell surface expression of glycosphingolipids caused by vitamin E in cultured murine (K3T3) reticulum sarcoma cells.

Authors:  G Yogeeswaran; I N Mbawuike
Journal:  Lipids       Date:  1986-10       Impact factor: 1.880

10.  Cholera toxin and cell growth: role of membrane gangliosides.

Authors:  M D Hollenberg; P H Fishman; V Bennett; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1974-10       Impact factor: 11.205
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