Literature DB >> 4356000

In vivo suppression of the immune response to alloantigen by cholera enterotoxin.

C S Henney, L M Lichtenstein, E Gillespie, R T Rolley.   

Abstract

The immune response of C57BL/6 mice to allogeneic (DBA/2) mastocytoma cell suspensions was profoundly suppressed by intraperitoneal administration of 1 mug cholera enterotoxin 4 days after antigenic stimulation. The immune response assayed 11 days after antigen showed decreased cytolytically active thymusderived (T) lymphocytes and markedly depressed serumagglutinating titers. A comparable suppression of the immune response to skin allografts (DBA/2-->C57BL/6) was also effected by cholera toxin administration, although there was no prolongation of allograft survival. The mechanism of the immune suppression is apparently related to the known adenylate cyclase stimulatory activities of choleragen.

Entities:  

Mesh：

Substances：

Year:  1973        PMID： 4356000      PMCID： PMC302553          DOI： 10.1172/JCI107481

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  16 in total

1.  A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate.

Authors:  B L Brown; J D Albano; R P Ekins; A M Sgherzi
Journal:  Biochem J       Date:  1971-02       Impact factor: 3.857

2.  The role of cyclic AMP in the cytolytic activity of lymphocytes.

Authors:  C S Henney; L M Lichtenstein
Journal:  J Immunol       Date:  1971-08       Impact factor: 5.422

3.  Effect of cyclic 3',5'-adenosine monophosphate and theophylline on lymphocyte transformation.

Authors:  R Hirschhorn; J Grossman; G Weissmann
Journal:  Proc Soc Exp Biol Med       Date:  1970-04

4.  In vitro induction of a heterograft reaction: immunological parameters of the sensitization of rat lymphocytes against mouse cells in vitro.

Authors:  G Berke; W R Clark; M Feldman
Journal:  Transplantation       Date:  1971-10       Impact factor: 4.939

Review 5.  Cytotoxic effects of lymphoid cells in vitro.

Authors:  P Perlmann; G Holm
Journal:  Adv Immunol       Date:  1969       Impact factor: 3.543

6.  Specific in vitro cytotoxicity of thymus-derived lymphocytes sensitized to alloantigens.

Authors:  J C Cerottini; A A Nordin; K T Brunner
Journal:  Nature       Date:  1970-12-26       Impact factor: 49.962

7.  Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.

Authors:  K T Brunner; J Mauel; J C Cerottini; B Chapuis
Journal:  Immunology       Date:  1968-02       Impact factor: 7.397

8.  Quantitation of the cell-mediated immune response. I. The number of cytolytically active mouse lymphoid cells induced by immunization with allogeneic mastocytoma cells.

Authors:  C S Henney
Journal:  J Immunol       Date:  1971-12       Impact factor: 5.422

9.  Production of highly purified choleragen and choleragenoid.

Authors:  R A Finkelstein; J J LoSpalluto
Journal:  J Infect Dis       Date:  1970-05       Impact factor: 5.226

10.  Human lymphocytic metabolism. Effects of cyclic and noncyclic nucleotides on stimulation by phytohemagglutinin.

Authors:  J W Smith; A L Steiner; C W Parker
Journal:  J Clin Invest       Date:  1971-02       Impact factor: 14.808
View more
  11 in total

Review 1.  Suppression of the immune response by microorganisms.

Authors:  J H Schwab
Journal:  Bacteriol Rev       Date:  1975-06

2.  Modulating action of Escherichia coli heat-stable enterotoxin (STa) on the humoral immune response.

Authors:  M R Zucato; F A Dawood; L C Ricci; M G Costa; A F Pestana de Castro
Journal:  Med Microbiol Immunol       Date:  1988       Impact factor: 3.402

3.  Viral infection-homograft interactions in a murine model.

Authors:  J D Hamilton; J F Fitzwilliam; K S Cheung; J Shelburne; D J Lang; D B Amos
Journal:  J Clin Invest       Date:  1978-12       Impact factor: 14.808

4.  Lymphopenia and impaired immunological activities of splenocytes during the immune response to cholera enterotoxin.

Authors:  J R Kateley; J Holderbach; H Friedman
Journal:  Immunology       Date:  1978-10       Impact factor: 7.397

5.  Suppression of local intestinal immunoglobulin A immune response to cholera toxin by subcutaneous administration of cholera toxoids.

Authors:  S R Hamilton; J H Yardley; G D Brown
Journal:  Infect Immun       Date:  1979-05       Impact factor: 3.441

6.  Role for macrophages and thymus-derived lymphocytes in cholera toxin-induced immunosuppression.

Authors:  S F Lyons; H Friedman
Journal:  Infect Immun       Date:  1978-05       Impact factor: 3.441

7.  Stimulation of monocyte cGMP by leukocyte dialysates. An antigen-independent property of dialyzable transfer factor.

Authors:  J A Sandler; T K Smith; V C Manganiello; C H Kirkpatrick
Journal:  J Clin Invest       Date:  1975-11       Impact factor: 14.808

8.  cAMP antagonizes interleukin 2-promoted T-cell cycle progression at a discrete point in early G1.

Authors:  K W Johnson; B H Davis; K A Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

9.  Intercellular immunological controls and modulation of cyclic AMP levels. Some doubts.

Authors:  M C Berenbaum; E C Purves; I E Addison
Journal:  Immunology       Date:  1976-06       Impact factor: 7.397

10.  Treatment of autoimmune MRL/Mp-lpr/lpr mice with cholera toxin.

Authors:  J L Fan; K Himeno; S Tsuru; K Nomoto
Journal:  Clin Exp Immunol       Date:  1987-10       Impact factor: 4.330
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.