Literature DB >> 4354229

Regulation of phosphodiesterase synthesis: requirement for cyclic adenosine monophosphate-dependent protein kinase.

H R Bourne, G M Tomkins, S Dion.   

Abstract

Endogenous cyclic adenosine monophosphate (AMP) and its dibutyryl derivative increase cyclic AMP phosphodiesterase activity in cultured lymphoma cells. This effect is prevented by cycloheximide. A variant population of cells deficient in cyclic AMP-dependent protein kinase contains lower basal phosphodiesterase activity, which cannot be induced by cyclic AMP.

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Year:  1973        PMID： 4354229     DOI： 10.1126/science.181.4103.952

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  14 in total

1.  A further study on the regulation of cyclic nucleotide phosphodiesterase activity in neuroblastoma cells: effect of growth.

Authors:  P K Sinha; K N Prasad
Journal:  In Vitro       Date:  1977-08

2.  Desensitization of the beta-adrenoceptor of lymphocytes from normal subjects and asthmatic patients in vitro.

Authors:  J K Greenacre; P Schofield; M E Conolly
Journal:  Br J Clin Pharmacol       Date:  1978-03       Impact factor: 4.335

3.  Cyclic AMP-dependent protein kinase mediates a cyclic AMP-stimulated decrease in ornithine and S-adenosylmethionine decarboxylase activities.

Authors:  P A Insel; J Fenno
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

4.  Desensitization of the beta-adrenoceptor of lymphocytes from normal subjects and patients with phaeochromocytoma: studies in vivo.

Authors:  J K Greenacre; M E Conolly
Journal:  Br J Clin Pharmacol       Date:  1978-03       Impact factor: 4.335

5.  The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP.

Authors:  J V Swinnen; D R Joseph; M Conti
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

6.  Induction of cyclic AMP phosphodiesterase in Blastocladiella emersonii and its relation to cyclic AMP metabolism.

Authors:  P M Epstein; P M Silverman
Journal:  J Bacteriol       Date:  1978-09       Impact factor: 3.490

7.  Prolonged prostaglandin E1 stimulation of cyclic AMP production in transformed and normal WI-38 fibroblasts.

Authors:  F J Chlapowski; K P Ray; R W Butcher
Journal:  In Vitro       Date:  1978-11

8.  A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells.

Authors:  J Hochman; P A Insel; H R Bourne; P Coffino; G M Tomkins
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

9.  Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells.

Authors:  J Hochman; H R Bourne; P Coffino; P A Insel; L Krasny; K L Melmon
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

10.  Cyclic AMP-mediated induction of the cyclic AMP phosphodiesterase of C-6 glioma cells.

Authors:  J P Schwartz; J V Passonneau
Journal:  Proc Natl Acad Sci U S A       Date:  1974-10       Impact factor: 11.205
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