Literature DB >> 4353428

MHPG excretion in depressive disorders: relation to clinical subtypes and desynchronized sleep.

J J Schildkraut, B A Keeler, M Papousek, E Hartmann.   

Abstract

The urinary excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG) was significantly lower in patients with manic-depressive depressions than in patients with chronic characterological depressions. There was an inverse relationship between MHPG excretion and the amount of time spent in desynchronized sleep, particularly in the manic-depressive disorders. Excretion of MHPG was not related to the degree of retardation, agitation, or anxiety in these patients.

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Year:  1973        PMID: 4353428     DOI: 10.1126/science.181.4101.762

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  3 in total

1.  Determination of 3-methoxy-4-hydroxyphenylglycol conjugates in urine. Application to the study of central noradrenaline metabolism in unmedicated chronic schizophrenic patients.

Authors:  M H Joseph; H F Baker; E C Johnstone; T J Crow
Journal:  Psychopharmacology (Berl)       Date:  1976-12-21       Impact factor: 4.530

2.  Fluvoxamine-a new serotonin re-uptake inhibitor: first clinical and psychometric experiences in depressed patients.

Authors:  B Saletu; M Schjerve; J Grünberger; H Schanda; O H Arnold
Journal:  J Neural Transm       Date:  1977       Impact factor: 3.575

Review 3.  Psychotherapeutic drugs and biogenic amines. Current concepts and therapeutic implications.

Authors:  W Z Potter
Journal:  Drugs       Date:  1984-08       Impact factor: 9.546

  3 in total

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