Literature DB >> 4352870

Action of botulinum toxin on transmission from sympathetic nerves to the vas deferens.

M E Holman, N C Spitzer.   

Abstract

Botulinum toxin (Type A) depressed or abolished transmission from postganglionic nerves to smooth muscle of isolated preparations of guinea-pig and mouse vas deferens. The time course of blockade was 2 to 6 times slower than that observed with the same concentration of the same batch of toxin on the rat diaphragm. Spontaneous excitatory junction potentials were still observed after 7 h exposure, indicating that the smooth muscle membrane was still able to respond to noradrenaline. Depression of transmission is probably due to a presynaptic action of unknown nature.

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Year:  1973        PMID： 4352870      PMCID： PMC1776555          DOI： 10.1111/j.1476-5381.1973.tb08343.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  The transmission of excitation from autonomic nerve to smooth muscle.

Authors:  G BURNSTOCK; M E HOLMAN
Journal:  J Physiol       Date:  1961-01       Impact factor: 5.182

2.  An intracellular study of the action of repetitive nerve volleys and of botulinum toxin on miniature end-plate potentials.

Authors:  V B BROOKS
Journal:  J Physiol       Date:  1956-11-28       Impact factor: 5.182

3.  The peripheral action of Cl. botulinum toxin.

Authors:  N Ambache
Journal:  J Physiol       Date:  1949-03-15       Impact factor: 5.182

4.  A further survey of the action of Clostridium botulinum toxin upon different types of autonomic nerve fibre.

Authors:  N AMBACHE
Journal:  J Physiol       Date:  1951-03       Impact factor: 5.182

5.  Miniature end-plate potentials at mammalian neuromuscular junctions poisoned by botulinum toxin.

Authors:  N Spitzer
Journal:  Nat New Biol       Date:  1972-05-03

6.  3 H-noradrenaline release and mechanical response in the field stimulated mouse vas deferens.

Authors:  L O Farnebo; T Malamfors
Journal:  Acta Physiol Scand Suppl       Date:  1971

7.  Postganglionic paralysis of the guinea-pig hypogastric nerve-vas deferens preparation by Clostridium botulinum type D toxin.

Authors:  D A Westwood; B C Whaler
Journal:  Br J Pharmacol Chemother       Date:  1968-05

8.  Impairment of sympathetic transmission by botulinum toxin.

Authors:  M J Rand; B C Whaler
Journal:  Nature       Date:  1965-05-08       Impact factor: 49.962

9.  The effect of type D botulinum toxin on frog neuromuscular junctions.

Authors:  A J Harris; R Miledi
Journal:  J Physiol       Date:  1971-09       Impact factor: 5.182
  9 in total
  6 in total

1.  Comparison of the presynaptic actions of botulinum toxin and beta-bungarotoxin on neuromuscular transmission.

Authors:  C C Chang; M C Huang
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

2.  Tetanus toxin and botulinum A toxin inhibit release and uptake of various transmitters, as studied with particulate preparations from rat brain and spinal cord.

Authors:  H Bigalke; I Heller; B Bizzini; E Habermann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-06       Impact factor: 3.000

Review 3.  Clostridium botulinum neurotoxin.

Authors:  H Sugiyama
Journal:  Microbiol Rev       Date:  1980-09

Review 4.  Botulinum toxins--cause of botulism and systemic diseases?

Authors:  H Böhnel; F Gessler
Journal:  Vet Res Commun       Date:  2005-05       Impact factor: 2.459

5.  Effectiveness and Safety of Intracavernosal IncobotulinumtoxinA (Xeomin®) 100 U as an Add-on Therapy to Standard Pharmacological Treatment for Difficult-to-Treat Erectile Dysfunction: A Case Series.

Authors:  Francois Giuliano; Pierre Denys; Charles Joussain
Journal:  Toxins (Basel)       Date:  2022-04-16       Impact factor: 5.075

6.  Impaired mitochondrial complex I function as a candidate driver in the biological stress response and a concomitant stress-induced brain metabolic reprogramming in male mice.

Authors:  Tim L Emmerzaal; Graeme Preston; Bram Geenen; Vivienne Verweij; Maximilian Wiesmann; Elisavet Vasileiou; Femke Grüter; Corné de Groot; Jeroen Schoorl; Renske de Veer; Monica Roelofs; Martijn Arts; Yara Hendriksen; Eva Klimars; Taraka R Donti; Brett H Graham; Eva Morava; Richard J Rodenburg; Tamas Kozicz
Journal:  Transl Psychiatry       Date:  2020-06-01       Impact factor: 6.222
  6 in total

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