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Literature DB >> 4350474

Enzyme release from polymorphonuclear leukocyte lysosomes: regulation by autonomic drugs and cyclic nucleotides.

Abstract

Osmotic release of beta-glucuronidase from polymorphonuclear leukocyte lysosomes is inhibited by catecholamines and adenosine 3',5'-monophosphate, and accelerated by cholinergic agents and guanosine 3',5'-monophosphate. These actions are specific for the sympathetic and parasympathetic neurotransmitters and for the two cyclic nucleotides, as phenylephrine, tyramine, choline, adenosine 5'-monophosphate and guanosine 5'-monophosphate do not inodify lysosomal enzyme release.

Entities: Chemical Gene

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Year: 1973 PMID： 4350474 DOI： 10.1126/science.180.4091.1181

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

16 in total

1. Sensitivity to cyclic nucleotides and to aspirin of the kininogen-consuming system activated by adrenaline or carbamylcholine in rat blood.

Authors: A M Rothschild; A Castania
Journal: Agents Actions Date: 1978-01

2. Modulation of the random migration of human platelets.

Authors: F H Valone; K F Austen; E J Goetzl
Journal: J Clin Invest Date: 1974-11 Impact factor: 14.808

Review 3. Regulation of lysosomal enzyme secretion: role in inflammation.

Authors: L J Ignarro
Journal: Agents Actions Date: 1974-10

4. Aspects of polymorph function in psoriasis.

Authors: J A Cotterill; M M Roberts; R Freeman; B King; K Mostoufi
Journal: Proc R Soc Med Date: 1974-09

5. Hormonal control of lysosomal enzyme release from human neutrophils: elevation of cyclic nucleotide levels by autonomic neurohormones.

Authors: L J Ignarro; W J George
Journal: Proc Natl Acad Sci U S A Date: 1974-05 Impact factor: 11.205

Enzyme release from polymorphonuclear leukocyte lysosomes: regulation by autonomic drugs and cyclic nucleotides.

1. Sensitivity to cyclic nucleotides and to aspirin of the kininogen-consuming system activated by adrenaline or carbamylcholine in rat blood.

2. Modulation of the random migration of human platelets.

Review 3. Regulation of lysosomal enzyme secretion: role in inflammation.

4. Aspects of polymorph function in psoriasis.

5. Hormonal control of lysosomal enzyme release from human neutrophils: elevation of cyclic nucleotide levels by autonomic neurohormones.

6. Identification of nicotinic acetylcholine receptors on lymphocytes in the periphery as well as thymus in mice.

7. Decreased H2 histamine response of granulocytes of asthmatic patients.

8. Beta-glucuronidase release from leukocytes in children.

9. The importance of calcium ions for the regulation of guanosine 3':5'-cyclic monophosphage levels.

10. Dimaprit inhibition of zymosan-stimulated beta-glucuronidase release from human granulocytes.