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Literature DB >> 434934

A structure-activity relationship of some chlorinated hydrocarbons.

Abstract

Partition coefficients of water/air, blood/air, oil/air, and oil/water for twenty chlorianted hydrocarbons, which were determined by means of a vial-equilibration method, were examined in relation to their chemical structures and threshold limit values (TLVs) recommended by the American Conference of Governmental Industrial Hygienists. The TLV was correlated closely with the blood/air partition coefficient and with the product of the water/air and the oil/air partition coefficient except for carbon tetrachloride and o-dichlorobenzene. A relation between partition coefficients and toxicity of these hydrocarbons is also described.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1979 PMID： 434934 DOI： 10.1080/00039896.1979.10667371

Source DB: PubMed Journal: Arch Environ Health ISSN： 0003-9896

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Cited

23 in total

1. Use of linear free energy relationships in toxicology: prediction of partition coefficients of volatile lipophilic compounds.

Authors: G A Csanády; R J Laib
Journal: Arch Toxicol Date: 1990 Impact factor: 5.153

2. Impact of airway gas exchange on the multiple inert gas elimination technique: theory.

Authors: Joseph C Anderson; Michael P Hlastala
Journal: Ann Biomed Eng Date: 2010-03 Impact factor: 3.934

Review 3. The closed chamber technique--uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors.

Authors: J G Filser
Journal: Arch Toxicol Date: 1992 Impact factor: 5.153

A structure-activity relationship of some chlorinated hydrocarbons.

1. Use of linear free energy relationships in toxicology: prediction of partition coefficients of volatile lipophilic compounds.

2. Impact of airway gas exchange on the multiple inert gas elimination technique: theory.

Review 3. The closed chamber technique--uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors.

4. Pollution due to volatile halocarbon compounds in biota.

5. Determination and prediction of tissue-gas partition coefficients.

6. Partition coefficients of some industrial aliphatic hydrocarbons (C5-C7) in blood and human tissues.

7. 1,1,1-Trichloroethane exposure, biologic monitoring by breath and urine analyses.

8. Experimental study on the pulmonary absorption and excretion of toluene.

9. Inhalation pharmacokinetics of 1,2-dichloroethane after different dietary pretreatments of male Sprague-Dawley rats.

10. Alveolar sampling and fast kinetics of tetrachloroethene in man. II. Fast kinetics.