Literature DB >> 4346035

Mutagenic DNA polymerase in human leukemic cells.

C F Springgate, L A Loeb.   

Abstract

Evidence is presented that DNA polymerases from human leukemic cells are mutagenic. Nucleic acid-free extracts of acute lymphoblastic leukemic cells polymerized about 10-times more dCTP using poly(dA-dT).poly(dA-dT) as a template than did extracts from normal lymphocytes. Mutagenic DNA polymerases could perhaps play an important role in tumor progression.

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Year:  1973        PMID： 4346035      PMCID： PMC433224          DOI： 10.1073/pnas.70.1.245

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Hydrolysis of template and newly synthesized deoxyribonucleic acid by the 3' to 5' exonuclease activity of the T4 deoxyribonucleic acid polymerase.

Authors:  M S Hershfield; N G Nossal
Journal:  J Biol Chem       Date:  1972-06-10       Impact factor: 5.157

2.  Enzymatic synthesis of deoxyribonucleic acid. 36. A proofreading function for the 3' leads to 5' exonuclease activity in deoxyribonucleic acid polymerases.

Authors:  D Brutlag; A Kornberg
Journal:  J Biol Chem       Date:  1972-01-10       Impact factor: 5.157

3.  An in vitro transversion by a mutationally altered T4-induced DNA polymerase.

Authors:  Z W Hall; I R Lehman
Journal:  J Mol Biol       Date:  1968-09-28       Impact factor: 5.469

4.  Enzymatic synthesis of deoxyribonucleic acid. XXVI. Physical and chemical studies of a homogeneous deoxyribonucleic acid polymerase.

Authors:  T M Jovin; P T Englund; L L Bertsch
Journal:  J Biol Chem       Date:  1969-06-10       Impact factor: 5.157

5.  Molecular association of DNA polymase with chromatin in sea urchin embryos.

Authors:  L A Loeb
Journal:  Nature       Date:  1970-05-02       Impact factor: 49.962

6.  Purification and properties of deoxyribonucleic acid polymerase from nuclei of sea urchin embryos.

Authors:  L A Loeb
Journal:  J Biol Chem       Date:  1969-04-10       Impact factor: 5.157

7.  Antimutagenic DNA polymerases of bacteriophage T4.

Authors:  J W Drake; E F Allen
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1968

8.  Induction of DNA polymerase in human lymphocytes by phytohemagglutinin.

Authors:  L A Loeb; S S Agarwal; A M Woodside
Journal:  Proc Natl Acad Sci U S A       Date:  1968-11       Impact factor: 11.205

9.  Mutagenic DNA polymerase.

Authors:  J F Speyer
Journal:  Biochem Biophys Res Commun       Date:  1965-10-08       Impact factor: 3.575

10.  A mechanism for keeping mutations in check.

Authors:  A L Koch; C Miller
Journal:  J Theor Biol       Date:  1965-01       Impact factor: 2.691
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  12 in total

1.  The presence of terminal deoxynucleotidyl transferase in the N-methyl-N-nitrosourea induced leukaemia in BDF1 mice and its effect on the accuracy of the DNA polymerases.

Authors:  R Saffhill; L Chaudhuri
Journal:  Nucleic Acids Res       Date:  1976-01       Impact factor: 16.971

2.  DNA polymerases alpha, delta, and epsilon of Novikoff hepatoma cells differ from those of normal rat liver in physicochemical and catalytic properties.

Authors:  O Popanda; G Fox; H W Thielmann
Journal:  J Mol Med (Berl)       Date:  1995-05       Impact factor: 4.599

3.  Reduced in vivo mutagenesis by mutant herpes simplex DNA polymerase involves improved nucleotide selection.

Authors:  J D Hall; P A Furman; M H St Clair; C W Knopf
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

Review 4.  [Molecular biology of the lymphocyte of the chronic lymphocytic leukemia (author's transl)].

Authors:  S Seeber; C G Schmidt
Journal:  Klin Wochenschr       Date:  1974-12-01

5.  Preferential inhibition of DNA polymerases alpha, delta, and epsilon from Novikoff hepatoma cells by inhibitors of cell proliferation.

Authors:  G Fox; O Popanda; L Edler; H W Thielmann
Journal:  J Cancer Res Clin Oncol       Date:  1996       Impact factor: 4.553

Review 6.  Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.

Authors:  E M Witkin
Journal:  Bacteriol Rev       Date:  1976-12

7.  Decreased fidelity of DNA polymerase activity during N-2-fluorenylacetamide hepatocarcinogenesis.

Authors:  J Y Chan; F F Becker
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

8.  Fidelity of deoxyribonucleic acid polymerases from normal and leukaemic human cells in polydeoxynucleotide replication.

Authors:  B I Srivastava
Journal:  Biochem J       Date:  1974-08       Impact factor: 3.857

9.  The modification of induced genetic change in yeast by an amino acid analogue.

Authors:  P J Davies; J M Parry
Journal:  Mol Gen Genet       Date:  1978-06-14

10.  Adriamycin and daunorubicin inhibition of mutant T4 DNA polymerases.

Authors:  M F Goodman; M J Bessman; N R Bachur
Journal:  Proc Natl Acad Sci U S A       Date:  1974-04       Impact factor: 11.205
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