Literature DB >> 4345904

Triglyceride storage disease: a disorder of lipolysis in adipose tissue in two patients.

C Gilbert, D J Galton, J Kaye.   

Abstract

An obese patient was studied whose adipose tissue showed a significant reduction in release of glycerol (P < 0.05) when stimulated by isoprenaline despite normal rises in tissue levels of cyclic-AMP. However, lipolysis was stimulated by a fast of 14 days as judged by weight loss and a rise in plasma fatty acids from 0.4 to 1.2 mM. The defect in this patient may be familial since her obese daughter also showed diminished release of glycerol from adipose tissue on three occasions when stimulated by isoprenaline, despite normal rises in levels of cyclic-AMP.

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Year:  1973        PMID： 4345904      PMCID： PMC1588521          DOI： 10.1136/bmj.1.5844.25

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  6 in total

1.  A rapid enzymatic assay for glycerol.

Authors:  P B GARLAND; P J RANDLE
Journal:  Nature       Date:  1962-12-08       Impact factor: 49.962

2.  Response of plasma NEFA levels to epinephrine infusions in normal and obese women.

Authors:  R D ORTH; R H WILLIAMS
Journal:  Proc Soc Exp Biol Med       Date:  1960-05

3.  A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate.

Authors:  B L Brown; J D Albano; R P Ekins; A M Sgherzi
Journal:  Biochem J       Date:  1971-02       Impact factor: 3.857

4.  Loss of cyclic 3'5'-AMP dependent kinase and reduction of phosphorylase kinase in skeletal muscle of a girl with deactivated phosphorylase and glycogenosis of liver and muscle.

Authors:  G Hug; W K Schubert; G Chuck
Journal:  Biochem Biophys Res Commun       Date:  1970-08-24       Impact factor: 3.575

5.  Studies on the role of RNA and protein synthesis in the lipolytic action of growth hormone in isolated fat cells.

Authors:  J N Fain
Journal:  Adv Enzyme Regul       Date:  1967

6.  Studies on adipose tissue from obese patients with or without diabetes mellitus. I. Release of glycerol and free fatty acids.

Authors:  P Björntorp; B Hood
Journal:  Acta Med Scand       Date:  1966-02
  6 in total
  1 in total

1.  Hormonal control of lipolysis.

Authors:  D J Galton
Journal:  Proc R Soc Med       Date:  1974-06
  1 in total

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