Literature DB >> 4344367

Hyporeactivity of infection: potential limitation to therapeutic use of interferon-inducing agents.

D A Stringfellow, L A Glasgow.   

Abstract

Interferon inducers are generally most effective as antiviral agents when used prophylactically. One possible explanation for this is that animals develop a state of hyporeactivity during the course of a virus infection. Such a progressive loss of capacity to produce interferon was observed with a representative group of interferon-inducing agents (polyinosinic-cytidylic acid, Tilorone hydrochloride, New-castle disease virus, or a strain of encephalomyocarditis virus) during the course of a model picornavirus infection in mice.

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Year:  1972        PMID： 4344367      PMCID： PMC422604          DOI： 10.1128/iai.6.5.743-747.1972

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  14 in total

Review 1.  Prospects for the use of double-stranded ribonucleic acid (poly I:C) inducers in man.

Authors:  M R Hilleman
Journal:  J Infect Dis       Date:  1970-02       Impact factor: 5.226

2.  Studies of relationship between mouse cytomegalovirus and interferon.

Authors:  J E Osborn; D N Medearis
Journal:  Proc Soc Exp Biol Med       Date:  1966-03

3.  Suppression of interferon and antibody and multiplication of Newcastle disease virus in cytomegalovirus infected mice.

Authors:  J E Osborn; D N Medearis
Journal:  Proc Soc Exp Biol Med       Date:  1967-02

Review 4.  Current concepts of interferon and interferon induction.

Authors:  E De Clercq; T C Merigan
Journal:  Annu Rev Med       Date:  1970       Impact factor: 13.739

5.  Interferon appearance stimulated by endotoxin, bacteria, or viruses in mice pre-treated with Escherichia coli endotoxin or infected with Mycobacterium tuberculosis.

Authors:  J S Youngner; W R Stinebring
Journal:  Nature       Date:  1965-10-30       Impact factor: 49.962

6.  Inducers of interferon and host resistance. VI. Antiviral efficacy of poly I:C in animal models.

Authors:  M M Nemes; A A Tytell; G P Lampson; A K Field; M R Hilleman
Journal:  Proc Soc Exp Biol Med       Date:  1969-11

7.  Kinetics of serum interferon response in mice after single and multiple injections of polyI-poly C.

Authors:  C E Buckler; H G DuBuy; M L Johnson; S Baron
Journal:  Proc Soc Exp Biol Med       Date:  1971-02

8.  Herpetic keratoconjunctivitis: therapy with synthetic double-stranded RNA.

Authors:  J H Park; S Baron
Journal:  Science       Date:  1968-11-15       Impact factor: 47.728

9.  Polyinosinic-cytidylic acid complex (poly I:C) and viral infections in mice.

Authors:  H F Lindh; H L Lindsay; B R Mayberry; M Forbes
Journal:  Proc Soc Exp Biol Med       Date:  1969-10

10.  Factors modifying host resistance to viral infection. 3. Effect of whole body x-irradiation on experimental encephalomyocarditis virus infection in mice.

Authors:  B R Murphy; L A Glasgow
Journal:  J Exp Med       Date:  1968-05-01       Impact factor: 14.307
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  11 in total

1.  Variable effect of encephalomyocarditis virus on host defense mechanisms.

Authors:  H Faden; L A Glasgow; J C Overall
Journal:  Infect Immun       Date:  1978-01       Impact factor: 3.441

2.  Comparation interferon- inducing and antiviral properties of 2-amino-5-bromo-6-methyl-4-pyrimidinol (U-25,166), tilorone hydrochloride, and polyinosinic-polycytidylic acid.

Authors:  D A Stringfellow
Journal:  Antimicrob Agents Chemother       Date:  1977-06       Impact factor: 5.191

3.  Heterologous gamma globulin as interferon inducer: differences in the properties of aggregated and aggregate-free gamma globulin preparations.

Authors:  L Priimägi; S Ioks; A Kulberg
Journal:  Arch Virol       Date:  1975       Impact factor: 2.574

4.  Hyporeactivity to interferon induction: characterization of a hyporeactive factor in the serum of encephalomyocarditis virus-infected mice.

Authors:  D A Stringfellow
Journal:  Infect Immun       Date:  1975-02       Impact factor: 3.441

5.  Murine leukemia: depressed response to interferon induction correlated with a serum hyporeactive factor.

Authors:  D A Stringfellow
Journal:  Infect Immun       Date:  1976-02       Impact factor: 3.441

6.  Herpesvirus hominis infection in newborn mice: treatment with interferon inducer polyinosinic-polycytidylic acid.

Authors:  E R Kern; J C Overall; L A Glasgow
Journal:  Antimicrob Agents Chemother       Date:  1975-06       Impact factor: 5.191

7.  Induction of interferon in mice by mycoplasmas.

Authors:  C R Rinaldo; B C Cole; J C Overall; L A Glasgow
Journal:  Infect Immun       Date:  1974-12       Impact factor: 3.441

8.  Hyporeactivity due to infection: recognition of a transferable hyporeactive factor in the serum of encephalomyocarditis virus-infected mice.

Authors:  D A Stringfellow; L A Glasgow
Journal:  Infect Immun       Date:  1974-12       Impact factor: 3.441

9.  Interferon induction in cynomolgus and rhesus monkey after repeated doses of a modified polyriboinosinic-polyribocytidylic acid complex.

Authors:  M L Sammons; E L Stephen; H B Levy; S Baron; D E Hilmas
Journal:  Antimicrob Agents Chemother       Date:  1977-01       Impact factor: 5.191

10.  Antiviral activity of BL-3849A, a low-molecular-weight oral interferon inducer.

Authors:  E R Kern; J R Hamilton; J C Overall; L A Glasgow
Journal:  Antimicrob Agents Chemother       Date:  1976-10       Impact factor: 5.191
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