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Literature DB >> 4342502

Bile acids: a pH dependent antibacterial system in the gut?

Abstract

Bile acids are secreted in the bile in the form of conjugates and many species of intestinal bacteria can rapidly deconjugate them. Studies have shown that an unconjugated bile acid may have bactericidal and bacteriostatic effects, which are pH dependent. It is proposed that unconjugated bile acids may be involved in a homoeostatic mechanism, preventing bacterial growth in the small intestine.

Entities: Chemical

Mesh：

Substances：

Year: 1972 PMID： 4342502 PMCID： PMC1786299 DOI： 10.1136/bmj.3.5830.813

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

13 in total

1. Resistance of vegetative cells of Clostridium welchii to low pH.

Authors: R G Sutton; B C Hobbs
Journal: J Med Microbiol Date: 1971-11 Impact factor: 2.472

2. Jejunal bacteriology and bile-salt metabolism in patients with intestinal malabsorption.

Authors: S Tabaqchali; C C Booth
Journal: Lancet Date: 1966-07-02 Impact factor: 79.321

3. Bile-salts in small intestinal contents after ileal resection and in other malabsorption syndromes.

Authors: G M McLeod; H S Wiggins
Journal: Lancet Date: 1968-04-27 Impact factor: 79.321

4. Partial biliary obstruction with cholangitis producing a blind loop syndrome.

Authors: A J Scott; G A Khan
Journal: Gut Date: 1968-04 Impact factor: 23.059

5. Studies of intestinal microflora. II. Microorganisms of the small intestine and their relations to oral and fecal flora.

Authors: S L Gorbach; A G Plaut; L Nahas; L Weinstein; G Spanknebel; R Levitan
Journal: Gastroenterology Date: 1967-12 Impact factor: 22.682

6. Bile salt metabolism in the normal human small intestine.

Authors: T C Northfield; E Condillac; I McColl
Journal: Gut Date: 1970-12 Impact factor: 23.059

7. Bacteria and aetiology of cancer of large bowel.

Authors: M J Hill; B S Drasar; G Hawksworth; V Aries; J S Crowther; R E Williams
Journal: Lancet Date: 1971-01-16 Impact factor: 79.321

8. Bile acid inhibition of the intestinal microflora--a function for simple bile acids?

Authors: M H Floch; W Gershengoren; S Elliott; H M Spiro
Journal: Gastroenterology Date: 1971-08 Impact factor: 22.682

9. Studies on the intestinal flora. II. Bacterial flora of the small intestine in patients with gastrointestinal disorders.

Authors: B S Drasar; M Shiner
Journal: Gut Date: 1969-10 Impact factor: 23.059

10. Bacteria, bile, and the small bowel.

Authors: S L Gorbach; S Tabaqchali
Journal: Gut Date: 1969-12 Impact factor: 23.059

10 in total

1. Editorial: Antibiotic diarrhoea.

Authors:
Journal: Br Med J Date: 1975-11-01

2. Reduced microbial transformation of bile acids in cystic fibrosis.

Authors: D Lefebvre; S Ratelle; L Chartrand; C C Roy
Journal: Experientia Date: 1977-05-15

3. Prebiotics from acorn and sago prevent high-fat-diet-induced insulin resistance via microbiome-gut-brain axis modulation.

Authors: Shokouh Ahmadi; Ravinder Nagpal; Shaohua Wang; Jason Gagliano; Dalane W Kitzman; Sabihe Soleimanian-Zad; Mahmoud Sheikh-Zeinoddin; Russel Read; Hariom Yadav
Journal: J Nutr Biochem Date: 2019-01-30 Impact factor: 6.048

Bile acids: a pH dependent antibacterial system in the gut?

1. Resistance of vegetative cells of Clostridium welchii to low pH.

2. Jejunal bacteriology and bile-salt metabolism in patients with intestinal malabsorption.

3. Bile-salts in small intestinal contents after ileal resection and in other malabsorption syndromes.

4. Partial biliary obstruction with cholangitis producing a blind loop syndrome.

5. Studies of intestinal microflora. II. Microorganisms of the small intestine and their relations to oral and fecal flora.

6. Bile salt metabolism in the normal human small intestine.

7. Bacteria and aetiology of cancer of large bowel.

8. Bile acid inhibition of the intestinal microflora--a function for simple bile acids?

9. Studies on the intestinal flora. II. Bacterial flora of the small intestine in patients with gastrointestinal disorders.

10. Bacteria, bile, and the small bowel.

1. Editorial: Antibiotic diarrhoea.

2. Reduced microbial transformation of bile acids in cystic fibrosis.

3. Prebiotics from acorn and sago prevent high-fat-diet-induced insulin resistance via microbiome-gut-brain axis modulation.

Review 4. Benefit and mischief from commensal bacteria.

Review 5. Prostaglandin pathways in duodenal chemosensing.

6. Deconjugation of bile acids by intestinal lactobacilli.

Review 7. Persistent Infection and Long-Term Carriage of Typhoidal and Nontyphoidal Salmonellae.

8. Postprandial concentrations of free and conjugated bile acids down the length of the normal human small intestine.

9. Sensitivity of Helicobacter pylori to different bile salts.

Review 10. Review: microbial transformations of human bile acids.