| Literature DB >> 434244 |
W O Shekim, H Dekirmenjian, J L Chapel.
Abstract
The authors studied the excretion of 3-methoxy-4-hydroxyphenlyglycol (MHPG) in 15 hyperactive boys and 13 controls. They further examined soft neurologic signs and clinical drug response to d-amphetamine administration for two weeks in the hyperactive boys. MHPG excretion was significantly lower in the hyperactive boys than in the controls. d-Amphetamine decreased MHPG excretion significantly in the drug responders only. Pretreatment MHPG excretion did not predict clinical drug response. The responders had more soft neurologic signs than the nonresponders. Furthermore, soft neurologic signs were not related to pretreatment MHPG levels.Entities:
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Year: 1979 PMID： 434244 DOI： 10.1176/ajp.136.5.667
Source DB: PubMed Journal: Am J Psychiatry ISSN： 0002-953X Impact factor: 18.112