Literature DB >> 4340158

Identification of lactate dehydrogenase isoenzymes by rapid kinetics.

M J Bishop, J Everse, N O Kaplan.   

Abstract

Stopped-flow kinetics indicate that human and chicken heart-type(4) lactate dehydrogenases (LDH) become inhibited as DPNH is oxidized in the presence of high concentrations of pyruvate. This inhibition is much less marked with the human and chicken muscle-type(4) enzymes. The initial rates and the difference in inhibition between the two types of enzyme have made it possible to determine the amount of, as well as the ratio between, the two types of LDH that are present in a given sample by a single kinetic assay. The stopped-flow kinetic method has been used to analyze amounts of LDH isoenzyme in different tissues, as well as in serum.

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Year:  1972        PMID： 4340158      PMCID： PMC426797          DOI： 10.1073/pnas.69.7.1761

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

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3.  THE COMPARATIVE ENZYMOLOGY OF LACTIC DEHYDROGENASES. II. PROPERTIES OF THE CRYSTALLINE HM3 HYBRID FROM CHICKEN MUSCLE AND OF H2M2 HYBRID AND H4 ENZYME FROM CHICKEN LIVER.

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Authors:  N O KAPLAN
Journal:  Brookhaven Symp Biol       Date:  1964-12

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